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Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): TRF2 and NBS1 function in redundant pathways to suppress nonhomologous end joining by promoting the generation of a 3' overhang after completion of leading-strand DNA synthesis. By using chromosome orientation-fluorescence in situ hybridization to distinguish between leading- and lagging-strand telomeres, we observed that, when TRF2 and NBS1 are simultaneously removed in TRF2F/F NBS1F/− mouse embryonic fibroblasts by the introduction of Cre recombinase, leading-strand (red) but not lagging-strand (green) telomeres become deprotected and fuse to one another. (See related article on p. 5552.)

Mol Cell Biol. 2009 October; 29(20): Cover