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Spatiotemporal map of yeast endocytosis.
The spatiotemporal localization of the constituent proteins for each protein module involved in endocytosis is represented as their lifetime (in seconds with representative bars drawn to scale) at the site of endocytic internalization. SH3 domain–containing proteins are shown in bold. The diagram at the top, in which the line represents the plasma membrane, graphically illustrates the dynamic recruitment of the four endocytic modules colored as follows: coat (green), WASP/Myo (yellow), scission (blue), and actin (red). The circle at the far right represents the nascent endocytic vesicle, which is released from the plasma membrane and internalized into the cell by an actin-based mechanism.