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Published online 2009 October 20. doi: 10.1371/journal.pbio.1000218

Figure 6

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Yeast SH3 domain interaction network underlying endocytosis.

SH3 domain–mediated interactions predicted by the Bayesian model are shown for endocytosis proteins. Interacting proteins were divided amongst their respective modules (coat, WASP/Myo, scission, and actin, represented as green, yellow, blue, and red circles, respectively) and are highlighted in green when known to be colocalized within a given module [29] at each time frame (in seconds) in endocytosis prior to vesicle internalization: (A) −120 to −40, (B) −40 to −35, (C) −35 to −25, (D) −25 to −15, (E) −15 to −10, and (F) −5 to 0. Disassembly of the endocytic vesicle and its concomitant internalization into the cytosol of the cell is taken as time 0 s, and therefore, all time points prior to this step are shown with negative time scales. Previously uncharacterized endocytosis proteins analyzed in this study are highlighted in red and assigned to their predicted endocytic module based on their SH3 domain interaction score (Table S13). The thickness of the edge is proportional to the Bayesian probability score for each interaction.

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