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From:
Published online 2009 October 20. doi: 10.1371/journal.pbio.1000218

Figure 4

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Yeast two-hybrid hits contain high-scoring PWM matches.

The phage-derived PWM for each SH3 domain was used to search the yeast proteome for matching peptides based on a PWM scoring algorithm, which ranks each peptide based on how closely it resembles the PWM. The fraction of yeast two-hybrid (Y2H) hits containing sequences with a rank score higher than the value on the x-axis is shown for: yeast two-hybrid interactions observed at least six times (solid line), yeast two-hybrid interactions observed at least one time (dashed line), and randomly chosen interactions (dotted line).

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