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The intrinsic specificities of yeast SH3 domains.
(A) SPt scores for yeast SH3 domain specificity profiles containing ten or more peptides. The values were determined for the PWMs shown in Figure 1, and the bars are colored according to the specificity class, as in Figure 1. (B) Contributions to SPt from different elements of SH3 domain specificity profiles. Contributions from proline or positively charged residues within the core binding motifs are colored black or grey, respectively, whereas contributions from positions outside of the core binding motifs are colored white. The core binding motifs for the various groups were defined as follows: class I (+XXPXXP), class II (PXXPX+), class III (poly-proline), unclassified Lsb1/Pin3 (+XXXPXP), and unclassified Boi1/Boi2 (PXXXPX+).