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[Cover image of issue]

Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): From foe to friend: the changing roles of p53 in simian virus 40 (SV40) transformation. The complex of SV40 T antigen (LT) with the tumor suppressor p53 has long served as a paradigm for the inactivation of p53 in tumorigenesis. Hermannstädadter et al. showed that the LT-p53 complex serves a dual purpose: elimination of p53's tumor suppressor functions and modulation of the transcriptional activity of LT by recruitment of transcriptional regulators via p53. The cover represents the changing roles of p53 in SV40 transformation as a chameleon sitting on a 3-dimensional model of the LT-p53 complex (green, LT; yellow, p53). The model of the complex is courtesy of X. Chen, University of Southern California, and W. Lilyestrom, Colorado State University. (See related article in October 2009, vol. 83, no. 19, p. 10106.)

J Virol. 2009 October; 83(20): Cover