1. Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of non-insulin dependent diabetes mellitus among adolescents. J Pediatr. 1996;128:608–615. [PubMed] 2. Dabelea D, Pettitt DJ, Jones KL, Arslanian SA. Type 2 diabetes mellitus in minority children and adolescents. An emerging problem. Endocrinol Metab Clin North Am. 1999;28:709–729. [PubMed] 3. Rosenbloom AL, Joe JR, Young RS, Winter WE. Emerging epidemic of type 2 diabetes in youth. Diabetes Care. 1999;22:345–354. [PubMed] 4. American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care. 2000;23:1–9. [PubMed] 5. Pinhas-Hamiel O, Standiford D, Hamiel D, Dolan LM, Cohen RM, Zeitler P. The type 2 family: a setting for development and treatment of adolescent type 2 diabetes. Arch Pediatr Adolesc Med. 1999;153:1063–1067. [PubMed] 6. Pinhas-Hamiel O, Zeitler P. Barriers to the treatment of adolescent type 2 diabetes – a survey of provider perceptions. Pediatr Diabetes. 2003;4:24–28. [PubMed] 7. Jones KL, Arslanian S, Peterokova VA, Park JS, Tomlinson MJ. Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial. Diabetes Care. 2002;25:89–94. [PubMed] 8. Silverstein JH, Rosenbloom AL. Treatment of type 2 diabetes mellitus in children and adolescents. J Pediatr Endocrinol Metab. 2000;13:1403–1409. [PubMed] 9. American Diabetes Association. Diagnosis and classification of diabetes. Diabetes Care. 2005;28:S37–S42. [PubMed] 10. Epstein LH, Valoski A, Wing RR, Mccurley J. Ten-year follow-up of behavioral family-based treatment for obese children. JAMA. 1990;264:2519–2523. [PubMed]
11. Dounchis JZ, Hayden HA, Wilfley DE. Obesity, body image, and eating disorders in ethnically diverse children and adolescents. In: Thompson JK, Smolak L, editors. Body Image, Eating Disorders, and Obesity in Youth: Assessment, Prevention, and Treatment. Washington, D.C: American Psychological Association; 2001. pp. 76–98.
12. Wrotniak BH, Epstein LH, Paluch RA, Roemmich JN. Parent weight change as a predictor of child weight change in family-based behavioral obesity treatment. Arch Pediatr Adolesc Med. 2004;158:342–347. [PubMed]
13. Epstein LH, Wilfley DE. Today Lifestyle Program Youth and FSP Handbooks and Treatment Manuals. 2005
14. Faith MS, Saelens BE, Wilfley DE, Allison DB. Behavioral treatment of childhood and adolescent obesity: current status, challenges, and future directions. In: Thompson JK, Smolak L, editors. Body Image, Eating Disorders, and Obesity in Youth: Assessment, Prevention, and Treatment. Washington, D.C: American Psychological Association; 2001. pp. 313–340.
15. Morgan CM, Tanofsky-Kraff M, Wilfley DE, Yanovski JA. Childhood obesity. Child Adolesc Psychiatr Clin N Am. 2002;11:257–278. [PubMed]
16. Wing RR. Treatment of obesity in patients with type 2 diabetes. In: Fairburn CG, Brownell KD, editors. Eating Disorders and Obesity. New York: Guilford Press; 2002. pp. 578–582.
17. Barlow SE, Dietz WH. Obesity evaluation and treatment: Expert Committee recommendations. The Maternal and Child Health Bureau, Health Resources and Services Administration and the Department of Health and Human Services. Pediatrics. 1998. p. E29. [PubMed]
18. Perri MG, Corsica JA. Improving the maintenance of weight loss in behavioral treatment of obesity. In: Wadden TA, Stunkard AJ, editors. Handbook of Obesity Treatment. New York: Guilford Press; 2002. pp. 357–379.
19. Epstein LH, Myers MD, Raynor HA, Saelens BE. Treatment of pediatric obesity. Pediatrics. 1998;101:554–570. [PubMed]
20. Epstein LH. Development of evidence-based treatment for pediatric obesity. In: Kazdin AE, Weisz JR, editors. Evidence-based Psychotherapies for Children and Adolescents. New York: Guildford Publications; 2003. pp. 374–388.
21. Goldfield GS, Raynor HA, Epstein LH. Treatment of pediatric obesity. In: Stunkard AJ, Wadden TA, editors. Obesity: Theory and Therapy. New York: Guilford Press; 2002. pp. 532–555.
22. American Diabetes Association, National Institutes Of Diabetes, Digestive And Kidney Disease. The prevention or delay of type 2 diabetes. Diabetes Care. 2002;25:742–749. [PubMed] 23. Goldfield GS, Epstein LH. Can fruits and vegetables and activities substitute for snack foods. Health Psychol. 2002;21:299–303. [PubMed]
24. Corbin CB, Pangrazi RP, Lemasurier GC. Physical activity for children: current patterns and guidelines. President’s Council on Physical Fitness and Sports Research Digest. 2004;5:1–8.
25. Epstein LH, Valoski AM, Vara LS, Mccurley J, Wisniewski L, Kalarchian MA. Effects of decreasing sedentary behavior and increasing activity on weight change in obese children. Health Psychol. 1995;14:109–115. [PubMed] 26. Robinson TN. Behavioral treatment of childhood and adolescent obesity. Int J Obes Relat Metab Disord. 1999;23:S52–S57. [PubMed] 27. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419. [PubMed] 28. Hermans MP, Levy JC, Morris RJ, Turner RC. Comparison of tests of b-cell function across a range of glucose tolerance from normal to diabetes. Diabetes. 1999;48:1779–1786. [PubMed] 29. Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate, method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85:2402–2410. [PubMed] 30. Pouliot MC, Despres JP, Lemieux S, et al. Waist circumference and abdominal saggital diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol. 1994;73:460–468. [PubMed] 31. Mayer-Davis EJ, Vitolins MZ, Carmichael SL, et al. Validity and reproducibility of a food frequency interview in a Multi-Cultural Epidemiology Study. Ann Epidemiol. 1999;9:314–324. [PubMed] 32. Weston AT, Petosa R, Pate RR. Validation of an instrument for measurement of physical activity in youth. Med Sci Sports Exerc. 1997;29:138–143. [PubMed] 33. Melanson EL, Freedson PS. Validity of the Computer Science and Applications, Inc. (CSA) activity monitor. Med Sci Sports Exerc. 1995;27:934–940. [PubMed] 34. Boreham CA, Paliczka VJ, Nichols AK. A comparison of the PWC1709 and 20-MST tests of aerobic fitness in adolescent schoolchildren. J Sports Med Phys Fitness. 1990;30:19–23. [PubMed] 35. Feldman EL, Stevens MJ, Thomas PK, Brown MB, Canal N, Greene DA. A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care. 1994;17:1281–1289. [PubMed] 36. Kovacs M. Rating scales to assess depression in schoolage children. Acta Paedopsychiatr. 1981;46:305–310. [PubMed] 37. Kovacs M. The childrens depression inventory. Psychopharmacol Bull. 1985;21:995–998. [PubMed]
38. Kovacs M, Beck AT. An empirical-clinical approach toward a definition of childhood depression. In: Schulterbrandt JG, Raskin A, editors. Depression in Childhood: Diagnosis, Treatment, and Conceptual Models. New York: Raven Press; 1997. pp. 1–25.
39. Kovacs M. Children’s Depression Inventory Manual. North Tonawanda, NY: Multi-Health systems, Inc; 1992.
40. Reynolds WM. Depression in children and adolescents. In: Reynolds WM, editor. Internalizing Disorders in Children and Adolescents. New York: John Wiley & Sons, Inc; 1992.
41. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:53–63.
42. Beck AT, Steer RA, Garbin MG. Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev. 1988;8:77–100.
43. Beck AT, Steer RA. Beck Depression Inventory II. San Antonio: Psychological Corp; 1996.
44. Kendall PC, Hollon SD, Beck AT, Hammern CH, Ingram RE. Issues and recommendations regarding the use of the Beck Depression Inventory. Cognit Ther Res. 1987;11:289–299.
45. Landgraf JM, Abetz L, Ware JE. The CHQ User’s Manual. 1st edn. Boston, MA: The Health Institute New England Medical Center; 1996.
46. Varni Jw, Burwinkle TM, Jacobs JR, Gottschalk M, Kaufman F, Jones KL. The PedsQL in type 1 and type 2 diabetes: reliability and validity of the Pediatric Quality of Life inventory generic core scales and type 1 diabetes module. Diabetes Care. 2003;26:631–637. [PubMed] 47. Furlong WJ, Feeny DH, Torrance GW, Barr RD. The Health Utilities Index (HUI) system for assessing health-related quality of life in clinical studies. Ann Med. 2001;33:375–384. [PubMed] 48. Peduzzi P, Wittes J, Detre K, Holford T. Analysis as-randomized and the problem of non-adherence: an example from the Veterans Affairs Randomized Trial of Coronary Artery Bypass Surgery. Stat Med. 1993;12:1185–1195. [PubMed]
49. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data. New York: John Wiley & Sons, Inc; 1980. pp. 219–224.
50. The DCCT Research Group. The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the Diabetes Control and Complications Trial. Diabetes. 2005;44:968–983. [PubMed] 51. The DCCT Research Group. The effect of intensive diabetes treatment on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial. N Engl J Med. 2005;329:977–986. [PubMed]
52. Girard J. Fatty acids and beta cells. Diabetes Metab. 2000;26:S6–S9.
53. Greene DA. Rosiglitazone: a new therapy for type 2 diabetes. Expert Opin Investig drugs. 1999;8:1709–1719. [PubMed] 54. Mcgarry JD, Dobbins RL. Fatty acids, lipotoxicity and insulin secretion. Diabetologia. 1999;42:128–138. [PubMed] 55. Unger RH, Orci L. Lipotoxic diseases of nonadipose tissues in obesity. Int J Obes Relat Metab Disord. 2000;24:S28–S32. [PubMed] 56. Kimm SYS, Glynn NW, Kriska AM, et al. Longitudinal changes in physical activity in a biracial cohort during adolescence. Med Sci Sports Exerc. 2000;32:1445–1454. [PubMed] 57. Colditz GA, Willett WC, Stampfer MJ, London SJ, Segal MR, Speizer FE. Patterns of weight change and their relation to diet in a cohort of healthy women. Am J Clin Nutr. 1990;51:1100–1105. [PubMed] 58. Manson JE, Rimm EB, Stampfer MJ, et al. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet. 1991;338:774–778. [PubMed] 59. West KM, Kalbfleisch JM. Influence of nutritional factors on prevalence of diabetes. Diabetes. 1971;20:99–108. [PubMed] 60. Maggio CA, Pi-Sunyer FX. The prevention and treatment of obesity. Application to type 2 diabetes. Diabetes Care. 1997;20:1744–1766. [PubMed] 61. Blackburn G. Effect of degree of weight loss on health benefits. Obes Res. 1995;3:211s–216s. [PubMed] 62. Goldstein DJ. Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord. 1992;16:397–415. [PubMed] 63. Wing RR, Koeske R, Epstein LH, Nowalk MP, Gooding W, Becker D. Long-term effects of modest weight loss in type II diabetic patients. Arch Intern Med. 1987;147:1749–1753. [PubMed] 64. Henry RR, Wiest-Kent TA, Scheaffer L, Kolterman OG, Olefsky JM. Metabolic consequences of very-low-calorie diet therapy in obese non-insulin-dependent diabetic and nondiabetic subjects. Diabetes. 1986;35:155–164. [PubMed] 65. Lean ME, Powrie JK, Anderson AS, Garthwaite PH. Obesity, weight loss and prognosis in type 2 diabetes. Diabet Med. 1990;7:228–233. [PubMed] 66. Chaturvedi N, Fuller JH. The Who Multinational Study of Vascular Disease in Diabetes. Mortality risk by body weight and weight change in people with NIDDM. Diabetes Care. 1995;18:766–774. [PubMed] 67. Breda E, Cavaghan MK, Toffolo G, Polonsky KS, Cobelli C. Oral glucose tolerance test and minimal model indexes of beta-cell function and insulin sensitivity. Diabetes. 2001;50:150–158. [PubMed] 68. Stumvoll M, Mitrakou A, Pimenta W, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23:295–301. [PubMed] 69. Guzzaloni G, Grugni G, Mazzilli G, Moro D, Morabito F. Comparison between beta-cell function and insulin resistance indexes in prepubertal and pubertal obese children. Metabolism. 2002;51:1011–1016. [PubMed] 70. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care. 2000;23:57–63. [PubMed] 71. Uwaifo GI, Fallon EM, Chin J, Elberg J, Parikh SJ, Yanovski JA. Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care. 2002;25:2081–2087. [PubMed] 72. Roemmich JN, Clark PA, Lusk M, et al. Pubertal alterations in growth and body composition. VI. Pubertal insulin resistance: relation to adiposity, body fat distribution, and hormone release. Int J Obes Relat Metab Disord. 2002;26:701–709. [PubMed] 73. Kay JP, Alemzadeh R, Langley G, D’angelo L, Smith P, Holshouser S. Beneficial effects of metformin in normoglycemic morbidly obese adolescents. Metabolism. 2001;50:1457–1461. [PubMed] 74. Brownell KD, Kelman JH, Stunkard AJ. Treatment of obese children with and without their mothers: changes in weight and blood pressure. Pediatrics. 1983;71:515–523. [PubMed] 75. Goran MI, Driscoll P, Johnson R, Nagy TR. Cross-calibration of body composition techniques against dual-energy X-ray absorptiometry in young children. Am J Clin Nutr. 2005;63:299–305. [PubMed] 76. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393–403. [PMC free article] [PubMed] 77. Rockett HR, Breitenbach M, Frazier AL, et al. Validation of a youth/adolescent food frequency questionnaire. Prev Med. 1997;26:808–816. [PubMed] 78. Jacobs DR, Ainsworth BE, Hartman TJ, Leon AS. A simultaneous evaluation of 10 commonly used physical activity questionnaires. Med Sci Sports Exerc. 1993;25:81–91. [PubMed] 79. Kriska AM, Knowler WC, Laporte RE, et al. Development of a questionnaire to examine the relationship of physical activity and diabetes in Pima Indians. Diabetes Care. 1990;13:401–411. [PubMed] 80. Janz KF. Validation of the CSA accelerometer for assessing children’s physical activity. Med Sci Sports Exerc. 1994;26:369–375. [PubMed] 81. Nichols JF, Morgan CG, Chabot LE, Sallis JF, Calfas KJ. Assessment of physical activity with the Computer Science and Applications, Inc., accelerometer: laboratory versus field validation. Res Q Exerc Sport. 2000;71:36–43. [PubMed] 82. Masse LC, Fulton JE, Watson KL, et al. Detecting bouts of physical activity in a field setting. Res Q Exerc Sport. 1999;70:212–219. [PubMed] 83. Rowland TW, Cunningham LN. Oxygen uptake plateau during maximal treadmill exercise in children. Chest. 1992;101:485–489. [PubMed] 84. Howley ET, Bassett DR, Welch HG. Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc. 1995;27:1292–1301. [PubMed] 85. Reaven GM. 1988 Banting lecture: role of insulin resistance inhuman disease. Diabetes. 1988;37:1595–1607. [PubMed] 86. Zavaroni I, Mazza S, Luchetti L, et al. Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med. 1989;320:702–706. [PubMed] 87. Zavaroni I, Mazza S, Luchetti L, et al. High plasma insulin and triglyceride concentrations and blood pressure in offspring of people with impaired glucose tolerance. Diabet Med. 1990;7:494–498. [PubMed] 88. Kullo IJ, Gau GT, Tajik AJ. Novel risk factors for atherosclerosis. Mayo Clin Proc. 2000;75:369–380. [PubMed] 89. Srinivasan SR, Myers L, Berenson GS. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: the Bogalusa Heart Study. Diabetes. 2002;51:204–209. [PubMed] 90. Zieske AW, Malcolm GT, Strong JP. Natural history and risk factors of atherosclerosis in children and youth: the PDAY study. Pediatr Pathol Mol Med. 2002;21:213–237. [PubMed] 91. Ferguson MA, Gutin B, Owens S, Litaker M, Tracy RP, Allison J. Fat distribution and hemostatic measures in obese children. Am J Clin Nutr. 1998;67:1136–1140. [PubMed] 92. Gallistl S, Sudi KM, Aigner R, Borkenstein M. Changes in serum interleukin-6 concentrations in obese children and adolescents during a weight reduction program. Int J Obes Relat Metab Disord. 2001;25:1640–1643. [PubMed] 93. Sudi KM, Gallistl S, Payerl D, et al. Interrelationship between estimates of adiposity and body fat distribution with metabolic and hemostatic parameters in obese children. Metabolism. 2001;50:681–687. [PubMed] 94. Estelles A, Dalmau J, Falco C, et al. Plasma PAI-1 levels in obese children - effect of weight loss and influence of PAI-1 promoter 4G/5G genotype. Thromb Haemost. 2001;86:647–652. [PubMed] 95. Takahashi C, Nagai N, Ujihara N, et al. Clinical profile of Japanese dialysis patients with diabetic nephropathy, diagnosed as having diabetes before the age of thirty. Diabetes Res Clin Pract. 1990;10:127–131. [PubMed] 96. Yokoyama H, Okudaira M, Otani T, et al. Higher incidence of diabetic nephropathy in type 2 than in type 1 diabetes in early-onset diabetes in Japan. Kidney Int. 2000;58:302–311. [PubMed] 97. DCCT Research Group. Lifetime benefits and costs of intensive therapy as practiced in the diabetes control and complications trial. JAMA. 1996;276:1409–1415. [PubMed] 98. United Kingdom Prospective Diabetes Study Group. Cost effectiveness of an intensive blood glucose control policy in patients with type 2 diabetes: economic analysis alongside randomised controlled trial (UKPDS41) BMJ. 2000;320:1373–1378. [PMC free article] [PubMed] 99. The Collaborative Study Group. An economic analysis of captopril in the treatment of diabetic nephropathy. Diabetes Care. 1996;19:1051–1061. [PubMed]
100. Gold MR, Siegel JE, Russell LB, Weinstein MC. Cost-Effectiveness in Health and Medicine. New York: Oxford University Press; 1996. pp. 5–9.
101. Drummond MF, O’brien B, Stoddart GL, Torrance GW. Methods for the Economic Evaluation of Health Care Programmers. 2nd edn. New York: Oxford University Press; 1999. pp. 96–107.