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AAPS PharmSciTech. 2006 March; 7(1): E184–E191.
Published online 2006 March 24. doi:  10.1208/pt070126
PMCID: PMC2750733

Solubility prediction in octanol: A technical note

Summary

The purpose of this work was to derive an equation for the rapid estimation of octanol solubilities of organic compounds. Solubilities ranging over 4 orders of, magnitude were predicted with an average absolute error of 0.39 logarithmic units using melting point alone. The greatest error in prediction occurred for strongly bonded compounds.

Keywords: octanol solubility, activity coefficient, solubility parameter

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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