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AAPS PharmSciTech. 2006 March; 7(1): E146–E152.
Published online 2006 March 10. doi:  10.1208/pt070121
PMCID: PMC2750728

Micro-emultocrit technique: A valuable tool for determination of critical HLB value of emulsions

Abstract

The aim of this work was to develop a methodology for rapid determination of the critical hydrophilic-lipophilic balance (HLB) value of lipophilic fractions of emulsions. The emulsions were prepared by the spontaneous emulsification process with HLB value from 4.3 to 16.7. The preparations were stored at 2 different temperatures (25°C and 4°C) and their physicochemical behavior was evaluated by the micro-emultocrit technique and the long-term stability study. The experimental data show a reverse relationship between HLB values of the surfactant mixtures and emulsion stability. A close correlation between the results for both stability procedures was observed, suggesting the use of micro-emultocrit to predict stabilities of such systems. In addition, it was found that the critical HLB of the Mygliol 812 was 15.367.

Keywords: emulsions, hydrophilic-lipophilic balance, spontaneous emulsification process, micro-emultocrit, creaming index, stability

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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