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AAPS PharmSciTech. 2006 March; 7(1): E29–E32.
Published online 2006 January 13. doi:  10.1208/pt070104
PMCID: PMC2750711

Determination of aqueous solubility by heating and equilibration: A technical note

Summary and Conclusion

A modified shake-flask solubility method, where the equilibration time was shortened through heating, was used to determine the solubility of 48 different drugs and pharmaceutical excipients in pure water at room temperature. The heating process accelerates dissolution of the solid compound and frequently results in supersaturated solution. Seeding with the solid compound after heating and cooling to room temperature promotes precipitation of the solid compound in its original stable form. This modified shake-flask method generates reliable and reproducible solubility data.

Keywords: solubility, solubility determination, shake-flask method

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Selected References

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