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The findings of this investigation thus conclusively demonstrate the promising role of concomitant therapy of liposomal TRE and BP gels in treating acne patients. Allthough their use improved the therapeutic response, more benefits of the liposomal form of drugs were observed in terms of reduction in adverse effects of therapy, thus fostering better patient compliance. It can be concluded that this study underscores the potential utility of concomitant therapy with liposomal TRE and BP gels in the treatment of acne. However, the role of liposmal formulations may only be established after clinical evaluation of alarge number of patients, with a special focus on the adverse symptoms of therapy.