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AAPS PharmSciTech. 2007 September; 8(3): E152–E157.
Published online 2007 August 31. doi:  10.1208/pt0803071
PMCID: PMC2750567

Effect of curing on water diffusivities in acrylate free films as measured via a sorption technique

Abstract

Studies were performed to investigate the effect of curing on the diffusion coefficients of water, as measured via the sorption technique, in acrylate polymeric films. The mathematical model selected for obtaining diffusion constants from the vapor-phase sorption studies was derived from the longtime Fourier equation used for diffusion into a planar sheet. For Eudragit NE films, the diffusion coefficients of water decreased continuously until a constant minimum value was reached. Diffusion coefficients in Eudragit RS films decreased initially but increased beyond 4 hours of curing at 70δC and 90°C. This latter result suggested the possible evaporation of plasticizer, which also results in a more dramatic increase in glass transition temperature with curing for the Eudragit RS free film in comparison to the Eudragit NE free film. Such loss of plasticizer could also lead to the formation of molecular-scale channels within the films, which would result in increased film permeability. To verify this proposed explanation, the amounts of triethyl citrate plasticizer in Eudragit RS free films were determined using Fourier-transform infrared spectrophotometry. An optimal curing condition was predicted for Eudragit NE and Eudragit RS films based upon the curing conditions at which a minimum value of the diffusion coefficient was reached.

Keywords: Curing, acrylate coating, sorption, diffusion coefficient, glass transition temperature

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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