PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of aapspharmspringer.comThis journalToc AlertsSubmit OnlineOpen Choice
 
AAPS PharmSciTech. 2007 September; 8(3): E140–E144.
Published online 2007 August 24. doi:  10.1208/pt0803069
PMCID: PMC2750565

Statistical evaluation of influence of viscosity and content of polymer on dipyridamole release from floating matrix tablets: A technical note

Conclusion

The present investigation described the influence of viscosity and content of HPMC on dipyridamole release using 32 full factorial design. All formulations had desired floating lag time (<2 minutes) regardless of viscosity and content of polymeric matrices. Results of multiple regression analysis indicate that both factors significantly affect the diffusion exponent (n), release rate constant (k), and percentage drug release at 1 hour, 4 hours, 6 hours, and 12 hour, (P<.05). Mechanism of drug release was found to be anomalous type to case-II transport depending upon the viscosity and content of polymer. It was found that content of HPMC had a dominant role in the initial phase of drug release, while in the later phase viscosity of HPMC Predominated.

Keywords: Hydroxypropyl methylcellulose (HPMC), factorial design, floating tablets, dipyridamole

Full Text

The Full Text of this article is available as a PDF (292K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Baumgartner S, Kristl J, Vrecer F, Vodopivec P, Zorko B. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm. 2000;195:125–135. doi: 10.1016/S0378-5173(99)00378-6. [PubMed] [Cross Ref]
2. Yeole PG, Khan S, Patel VF. Floating drug delivery systems: need and development. Indian J Pharm Sci. 2005;67:265–272.
3. Kohri N, Miyata N, Takechi S, Nomura A. Evaluation of pH independent sustained release granules of dipyridamole by using gastric acidity controlled rabbits and human subjects. Int J Pharm. 1992;81:49–58. doi: 10.1016/0378-5173(92)90042-Z. [Cross Ref]
4. He X, Kadomura S, Takekuma Y, Sugawara M, Miyazaki K. A new system for the prediction of drug absorption using a pH controlled Caco-2 model: evaluation of pH dependent soluble drug absorption and pH related changes in absorption. J Pharm Sci. 2004;93:71–77. doi: 10.1002/jps.10518. [PubMed] [Cross Ref]
5. Vazquez MJ, Perez-Marcos B, Gomez-Amoza JL, Matinez-Pacheco R, Souto C, Concheiro A. Influence of technological variables on drug release of drug from hydrophilic matrices. Drug Dev Ind Pharm. 1992;18:1355–1375. doi: 10.3109/03639049209046332. [Cross Ref]
6. Ford JL, Rubinstein MH, Hogan JE. Formulation of sustained release promethazine hydrochloride tablet using HPMC matrices. Int J Pharm. 1985;24:327–337. doi: 10.1016/0378-5173(85)90031-6. [Cross Ref]
7. Campos-Aldrete ME, Villafuerte-Robles L. Influence of the viscosity grade and particle size of HPMC on metronidazole release matrix tablets. Eur J Pharm Biopharm. 1997;43:173–178. doi: 10.1016/S0939-6411(96)00004-5. [Cross Ref]
8. Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 1985;60:110–111. [PubMed]

Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists