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AAPS PharmSciTech. 2007 September; 8(3): E9–E12.
Published online 2007 July 6. doi:  10.1208/pt0803052
PMCID: PMC2750548

Monitoring ibuprofen release from multiparticulates: In situ fiber-optic technique versus the HPLC method: A technical note

Summary and conclusions

The results from the linearity test showed that the automated FOPS method was linear and reproducible in predicting ibuprofen concentrations, as was shown by a high R2 and low %RSD over a range of concentrations. Second-derivative treatment of the UV spectrum makes it possible to remove the effects of the sloping baseline often encountered in spectra of highly turbid samples. The dissolution profiles obtained by FOPS were more accurate with lower and consistent %RSD as compared with the HPLC method, particularly in the case of immediate-release multiparticulates. The FOPS method was also faster and less labor intensive.

Because of its various advantages, fiber-optic dissolution is fast becoming an important tool for research and development. Its ease of use, high “data density,” high data-collection speed, and hands-free monitoring make the FOPS method extremely useful as compared with the traditional methods of dissolution testing.

Keywords: Fiber-optic dissolution monitoring, ibuprofen, HPLC-UV analysis

Full Text

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists