Search tips
Search criteria 


Logo of aapspharmspringer.comThis journalToc AlertsSubmit OnlineOpen Choice
AAPS PharmSciTech. 2007 September; 8(3): E9–E12.
Published online 2007 July 6. doi:  10.1208/pt0803052
PMCID: PMC2750548

Monitoring ibuprofen release from multiparticulates: In situ fiber-optic technique versus the HPLC method: A technical note

Summary and conclusions

The results from the linearity test showed that the automated FOPS method was linear and reproducible in predicting ibuprofen concentrations, as was shown by a high R2 and low %RSD over a range of concentrations. Second-derivative treatment of the UV spectrum makes it possible to remove the effects of the sloping baseline often encountered in spectra of highly turbid samples. The dissolution profiles obtained by FOPS were more accurate with lower and consistent %RSD as compared with the HPLC method, particularly in the case of immediate-release multiparticulates. The FOPS method was also faster and less labor intensive.

Because of its various advantages, fiber-optic dissolution is fast becoming an important tool for research and development. Its ease of use, high “data density,” high data-collection speed, and hands-free monitoring make the FOPS method extremely useful as compared with the traditional methods of dissolution testing.

Keywords: Fiber-optic dissolution monitoring, ibuprofen, HPLC-UV analysis

Full Text

The Full Text of this article is available as a PDF (174K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Lu X, Lozano R, Shah P. In-situ dissolution testing using different UV fiber optic probes and instruments. Dissolution Technologies. 2003;10:6–16.
2. Wunderlich M, Way T, Dressman JB. Practical considerations when using fiber optics for dissolution testing. Dissolution Technologies. 2003;10:17–19.
3. Josefson M, Johansson E, Tortensson A. Optical fiber spectrometry in turbid solutions by multivariate calibration applied to tablet dissolution testing. Anal Chem. 1988;60:2666–2671. doi: 10.1021/ac00175a004. [PubMed] [Cross Ref]
4. Brown CW, Lin J. Interfacing a fiber-optic probe to a diode array UV-visible spectrophotometer for drug dissolution tests. Appl Spectrosc. 1993;47:615–618. doi: 10.1366/0003702934067261. [Cross Ref]
5. Chen CS, Brown CW. A drug dissolution monitor employing multiple fiber-optic probes and a UV/visible diode array spectrophotometer. Pharm Res. 1994;11:979–983. doi: 10.1023/A:1018975002025. [PubMed] [Cross Ref]
6. Gemperline PJ, Cho J, Baker B, Batchelor B, Walker DS. Determination of multicomponent dissolution profiles of pharmaceutical products by in situ fiber-optic UV measurements. Anal Chim Acta. 1997;345:155–159. doi: 10.1016/S0003-2670(97)00095-0. [Cross Ref]
7. Schatz C, Ulmschneider M, Altermatt R, Marrer S, Altorfer H. Thoughts on fiber optics in dissolution testing. Dissolution Technologies. 2001;8:6–13.
8. Martin CA. Evaluating the utility of fiber optic analysis for dissolution testing of drug products. Dissolution Technologies. 2003;10:37–40.
9. Toher CJ, Nielsen PE, Foreman AS, Avdeef A. In situ fiber optic dissolution monitoring of a vitamin B12 solid dosage formulation. Dissolution Technologies. 2003;10:20–25.
10. Inman GW. Quantitative assessment of probe and spectrometer performance for a multi-channel CCD-based fiber optic dissolution testing system. Dissolution Technologies. 2003;10:26–32.

Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists