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The results from the linearity test showed that the automated FOPS method was linear and reproducible in predicting ibuprofen concentrations, as was shown by a high R2 and low %RSD over a range of concentrations. Second-derivative treatment of the UV spectrum makes it possible to remove the effects of the sloping baseline often encountered in spectra of highly turbid samples. The dissolution profiles obtained by FOPS were more accurate with lower and consistent %RSD as compared with the HPLC method, particularly in the case of immediate-release multiparticulates. The FOPS method was also faster and less labor intensive.
Because of its various advantages, fiber-optic dissolution is fast becoming an important tool for research and development. Its ease of use, high “data density,” high data-collection speed, and hands-free monitoring make the FOPS method extremely useful as compared with the traditional methods of dissolution testing.