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AAPS PharmSciTech. 2005 June; 6(2): E198–E201.
Published online 2005 September 30. doi:  10.1208/pt060229
PMCID: PMC2750532

Monitoring the fluidized bed granulation process based onS-statistic analysis of a pressure time series

Abstract

Pressure fluctuation measurements collected during the fluidized bed granulation of pharmaceutical granule have been analyzed using the attractor comparison technique denoted as theS-statistic. Divergence of the bed state from the reference during granulation is followed by a return to a condition statistically similar to the original state of the dry fluidized ingredients on drying. This suggests insensitivity of theS-statistic technique to the changes in particle size distribution occurring during the granulation process. Consequently, the monitoring of pressure fluctuations alone may provide an easily implemented technique for the tracking of granule moisture and process end-point determination.

Key words: fluidized bed, granulation, S-statistic, hydrodynamics, chaos, pressure fluctuations

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists