PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of aapspharmspringer.comThis journalToc AlertsSubmit OnlineOpen Choice
 
AAPS PharmSciTech. 2004 December; 5(4): 101–106.
Published online 2004 September 17. doi:  10.1208/pt050464
PMCID: PMC2750489

Drug release properties of polyethylene-glycol-treated ciprofloxacin-Indion 234 complexes

Abstract

The polyethylene glycol (PEG) treatment of ciprofloxacin-Indion 234 complex was aimed to retard rapid ion exchange drug release at gastric pH. Ciprofloxacin loading on Indion 234 was performed in a batch process, and the amount of K+ in Indion 234 displaced by drug with time was studied as equilibrium constant KDM. Drug-resin complex (DRC) was treated with aqueous PEG solution (0.5%–2% wt/vol) of different molecular weights (MWs) for 2 to 30 minutes. The PEG-treated ciprofloxacin-Indion 234 complex was evaluated for particle size, water absorption time, and drug release at gastric pH. During drug loading on Indion 234, the equilibrium constant (KDM) increased rapidly up to 20 minutes with efficient drug loading. Increased time of immersion of the drug resinate in PEG solutions significantly retained higher size particles upon dehydration. The larger DRC particles showed longer water absorption times owing to compromised hydrating power. The untreated DRC showed insignificant drug release in deionized water; while at gastric pH, ciprofloxacin release was complete in 90 minutes. A trend of increased residual particle size, proportionate increase in water absorption time, and hence the retardation of release with time of immersion was evident in PEG-treated DRC. The time of immersion of DRC in PEG-treated DRC. The time of immersion of DRC in PEG solution had predominant release retardant effect, while the effect of molecular weight of PEG was insignificant. Thus, PEG treatment of DRC successfully retards ciprofloxacin ion exchange release in acidic pH.

Keywords: ciprofloxacin, Indion complexes, PEG immersion, particle size, water uptake, release

Full Text

The Full Text of this article is available as a PDF (338K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Borodkin SS. Ion exchange resins and sustained release. In: Swarbrick J, Boylan JC, editors. Encyclopedia of Pharmaceutical Technology. New York, NY: Marcel Dekker; 1984. pp. 203–216.
2. Novic M, Gucek M, Tursic J, Liu Y, Avadalovic N. Ion-exchange-based eluent-free preconcentration of some anions. J Chromatogr A. 2001;909:289–296. doi: 10.1016/S0021-9673(00)01109-2. [PubMed] [Cross Ref]
3. Liu Z, Cheung R, Wu XY, Ballinger JR, Bendayan R, Rauth AM. A study of doxorubicin loading onto and release from sulfopropyl dextran ion-exchange microspheres. J Control Release. 2001;77:213–224. doi: 10.1016/S0168-3659(01)00473-4. [PubMed] [Cross Ref]
4. Thairs S, Ruck S, Jackson SJ, Washington C. Effect of dose size, food and surface coating on the gastric residence and distribution of an ion exchange resin. Int J Pharm. 1998;176:47–53. doi: 10.1016/S0378-5173(98)00305-6. [Cross Ref]
5. Borodkin P, Sundberg PD. Polycarboxylic acid ion-exchange resin adsorbates for taste coverage in chewable tablets. J Pharm Sci. 1971;60:1523–1527. doi: 10.1002/jps.2600601018. [PubMed] [Cross Ref]
6. Hall SH. Sustained release from coated ion exchange resins. Paper presented at: Sixth International Symposium on Controlled Release of Bioactive Materials. August 1979. New Orleans, LA.
7. Cuna M, Vila JL, Torres D. Controlled release liquid suspensions based on ion-exchange particles trapped within acrylic microcapsules. Int J Pharm. 2000;199:151–158. doi: 10.1016/S0378-5173(00)00379-3. [PubMed] [Cross Ref]
8. Betty W, Michael P, Dokuzovic V, Lam V, inventors. Antitussive drugs delivered by ion exchange resins. US patent 6 001 392. December 14, 1999.
9. Imtiaz C, Patricia K, Edward R, Joel S. Sustained release oral suspensions. US patent 4 999 189. March 12, 1991.
10. Pham HH, Luo P, Genin F, Dash AK. Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying techniques. AAPS PharmSciTech. 2002;3(1):E1–E1. doi: 10.1208/pt030101. [PMC free article] [PubMed] [Cross Ref]
11. Santos L, Ghaly ES. Design and development of suspension containing drug resin complex [abstract].AAPS PharmSci. 2003;5(S1): Abstract T3257.
12. Vaviya S, Bajaj A. Oral controlled release bromhexine ion exchange resinate suspension formulation. Ind Drugs. 2000;37:185–189.
13. Cherukurri S, Chan T, inventors. Coated delivery system for cyclic amino acids with improved taste, texture and compressibility. Eur patent 045871. May 15, 1991.
14. Akkaramonkolporn P, Katsuhide T. Molecular properties of propranolol hydrochloride prepared as drug-resin complexes. Drug Dev Ind Pharm. 2001;27:359–364. doi: 10.1081/DDC-100103736. [PubMed] [Cross Ref]
15. Raghunanthan Y, Amsel L, Hinsvark ON, Bryant WJ. Sustain release drug delivery systems. I. Coated ion-exchange resin system for phenylpropanolamine and other drugs. J Pharm Sci. 1981;70:379–383. doi: 10.1002/jps.2600700409. [PubMed] [Cross Ref]
16. Conaghey OM, Coris J, Corrigan OI. The release of nicotine from a hydrogel containing ion exchange resins. Int J Pharm. 1998;170:215–224. doi: 10.1016/S0378-5173(98)00144-6. [Cross Ref]
17. Mahjani MS, Kolah AK, Sharma M. Extractive reactions with cationic exchange resins as catalysts (acetalization of aldehydes with alcohols) React Func Polym. 1995;28:29–38. doi: 10.1016/1381-5148(96)80152-0. [Cross Ref]
18. Glasstone S, Lewis D. Elements of Physical Chemistry. London, UK: Macmillan and Company Ltd; 1960.
19. Craig DQM. Polyethylene glycols and drug release. Drug Dev Ind Pharm. 1990;16:2501–2526. doi: 10.3109/03639049009058544. [Cross Ref]
20. Price JC. Polyethylene glycol. In: Kibbe AH, editor. Handbook of Pharmaceutical Excipients. Washington, DC: American Pharmaceutical Association and Pharmaceutical Press; 2000. pp. 392–398.
21. Jaskari T, Vuorio M, Kontturi K, Manzanares JA, Hirvonen J. Ionexchange fibers and drugs: an equilibrium study. J Control Release. 2001;70:219–229. doi: 10.1016/S0168-3659(00)00359-X. [PubMed] [Cross Ref]

Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists