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AAPS PharmSciTech. 2004 December; 5(4): 75–83.
Published online 2004 October 8. doi:  10.1208/pt050461
PMCID: PMC2750486

Melt solidification technique: Incorporation of higher wax content in ibuprofen beads


The purpose of this study was to achieve incorporation of a higher amount of wax during the preparation of ibuprofen beads by a melt solidification technique for better integrity and prolonged drug release by using a combination of waxes. A mixture of cetyl alcohol (CA) and palmitic acid (PA) was used to improve the matrix integrity and drug release. The effect of variables such as CA, PA, and speed of agitation were studied using 33 factorial design. Yield, crushing strength, and drug release were analyzed using response surface methodology. The in vitro dissolution test did not show any significant improvement in the drug release. Scanning electron microscopy (SEM) showed that beads were spherical with a smooth surface, but after dissolution became rough and porous. Differential scanning calorimetry (DSC) studies showed that different solidification and erosion properties of waxes are responsible for the inability of waxes to retard drug release even at higher concentration.

Keywords: ibuprofen, palmitic acid, cetyl alcohol, melt solidification, factorial design

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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