PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of aapspharmspringer.comThis journalToc AlertsSubmit OnlineOpen Choice
 
AAPS PharmSciTech. 2001 June; 2(2): 38–44.
Published online 2001 June 6. doi:  10.1208/pt020209
PMCID: PMC2750475

Multispectral imaging of tablets in blister packaging

Abstract

This experiment tested the hypothesis that using near-infrared (IR) imaging spectrometry on tablets through blister packs permits the identification and composition of multiple individual tablets to be determined simultaneously. Aspirin was selected for this study because its breakdown mechanism is well understood. Near-IR cameras were used to collect thousands of spectra simultaneously from a field of packaged aspirin tablets. Tablets were selected by a principal component analysis selection alogorithm. Graphs of the columns of the transformation matrix showed that salicylic acid and acetylsalicylic acid in the samples were modeled by the principal components. The bootstrap error-adjusted single-sample technique chemometric-imaging algorithm was used to draw probability-density contour plots that revealed tablet composition. Choice of color was used to represent constituent identity, whereas intensity represented concentration. The percentage of usable pixels in the indium antimonide (InSb) array was 99.9%. The SEP was 0.06% of the tablet mass for both water uptake and salicylic acid production. The number of tablets that a typical near-IR camera can currently analyze simultaneously was also estimated to be approximately 1300.

Keywords: Near-infrared, Probability, Map, Aspirin, Moisture

Full Text

The Full Text of this article is available as a PDF (196K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Lodder RA, Hieftje GM. Analysis of intact tablets by near-infrared reflectance spectrometry. Appl Spectrosc. 1988;42:556–558. doi: 10.1366/0003702884429201. [Cross Ref]
2. Lodder RA, Selby M, Hieftje GM. Detection of capsule tampering by near-infrared reflectance analysis. Anal Chem. 1987;59:1921–1930. doi: 10.1021/ac00142a008. [Cross Ref]
3. Lodder RA, Hieftje GM. Detection of subpopulations in near-infrared reflectance analysis. Appl Spectrosc. 1988;42:1500–1512. doi: 10.1366/0003702884429562. [Cross Ref]
4. Aldridge PK, Mushinsky RF, Andino MM, Evans CL. Appl Spectrosc. 1994;48:1272–1276. doi: 10.1366/0003702944027336. [Cross Ref]
5. Drennen JK, Lodder RA. Nondestructive near-infrared analysis of intact tablets for determination of degradation product. J Pharm Sci. 1990;79:622–627. doi: 10.1002/jps.2600790717. [PubMed] [Cross Ref]
6. Niemczyk TM, Delgado-Lopez MM, Allen FS. Quantitative determination of bucindolol concentration in intact gel capsules using Raman spectroscopy. Anal Chem. 1998;70(13):2762–2765. doi: 10.1021/ac971252u. [PubMed] [Cross Ref]
7. Dempsey RJ, Davis DG, Buice RG, Lodder RA. Biological and medical applications of near-infrared spectrometry. Appl Spectrosc. 1996;50(2):18A–34A. doi: 10.1366/0003702963906537. [Cross Ref]
8. Fischer M, Tran CD. Investigation of solid-phase peptide synthesis by the near-infrared multispectral imaging technique: a detection method for combinatorial chemistry. Anal Chem. 1999;71(13):2255–2261. doi: 10.1021/ac990207e. [PubMed] [Cross Ref]
9. Fischer M, Tran CD. Evidence for kinetic inhomogeneity in the curing of epoxy using the near-infrared multispectral imaging technique. Anal Chem. 1999;71(5):953–959. doi: 10.1021/ac981030b. [PubMed] [Cross Ref]
10. Tran CD, Cui Y, Smirnov S. Simultaneous multispectral imaging in the visible and near-infrared region: applications in document authentication and determination of chemical inhomogeneity of copolymers. Anal Chem. 1998;70(22):4701–4708. doi: 10.1021/ac980647q. [PubMed] [Cross Ref]
11. Ingle JD, Crouch SR. Spectrochemical analysis. Englewood Cliffs, NJ: Prentice-Hall; 1988.
12. Isaksson T, Kowalski B. Piece-wise multiplicative scatter correction applied to near-infrared diffuse transmittance data from meat products. Appl Spectrosc. 1993;47(6):702–709. doi: 10.1366/0003702934066839. [Cross Ref]
13. Dempsey RJ, Cassis LA, Davis DG, Lodder RA. Near infrared imaging and spectroscopy in stroke research: lipoprotein distributions and disease. Ann NY Acad Sci. 1997;820:149–169. doi: 10.1111/j.1749-6632.1997.tb46194.x. [PubMed] [Cross Ref]
14. Svensson O, Josefson M, Langkilde FW. Classification of chemically modified celluloses using a near-infrared spectrometer and soft independent modeling of class analogies. Appl Spectrosc. 1997;51(12):1826–1835. doi: 10.1366/0003702971939640. [Cross Ref]

Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists