Search tips
Search criteria 


Logo of aapspharmspringer.comThis journalToc AlertsSubmit OnlineOpen Choice
AAPS PharmSciTech. 2004 June; 5(2): 40–49.
Published online 2004 March 12. doi:  10.1208/pt050230
PMCID: PMC2750465

Spherical composite particles of rice starch and microcrystalline cellulose: A new coprocessed excipient for direct compression


Composite particles of rice starch (RS) and microcrystalline cellulose were fabricated by spray-drying technique to be used as a directly compressible excipient. Two size fractions of microcry stalline cellulose, sieved (MCS) and jet milled (MCJ), having volumetric mean diameter (D50) of 13.61 and 40.51 μm, respectively, were used to form composite particles with RS in various mixing ratios. The composite particles produced were evaluated for their powder and compression properties. Although an increase in the microcrystalline cellulose proportion imparted greater compressibility of the composite particles, the shape of the particles was typically less spherical with rougher surface resulting in a decrease in the degree of flowability. Compressibility of composite particles made from different size fractions of microcrystalline cellulose was not different; however, using MCJ, which had a particle size range close to the size of RS (D50=13.57 μm), provided more spherical particles than using MCS. Spherical composite particles between RS and MCJ in the ratio of 7[ratio]3 (RS-MCJ-73) were then evaluated for powder properties and compressibility in comparison with some marketed directly compressible diluents. Compressibility of RS-MCJ-73 was greater than commercial spray-dried RS (Eratab), coprocessed lactose and microcrystalline cellulose (Cellactose), and agglomerated lactose (Tablettose), but, as expected, lower than microcrystalline cellulose (Vivapur 101). Flowability index of RS-MCJ-73 appeared to be slightly lower than Eratab but higher than Vivapur 101, Cellactose, and Tablettose. Tablets of RS-MCJ-73 exhibited low friability and good self-disintegrating property. It was concluded that these developed composite particles could be introduced as a new coprocessed direct compression excipient.

Keywords: rice starch, microcrystalline cellulose, spray drying, coprocessed excipient, direct compression

Full Text

The Full Text of this article is available as a PDF (1.3M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Munoz-Ruiz A, Borrero-Rubio JM, Jimenez-Castellanos MR. Rheology of a new excipient for direct compression: Ludipress. Pharm Acta Helv. 1992;67:223–226.
2. Amstrong NA, Roscheisen G, Al-Aghbar MRAK. Cellactose as a tablet diluent. Manuf Chem. 1996;67:25–26.
3. Michoel A, Rombaut P, Verhoye A. Comparative evaluation of coprocessed lactose and microcrystalline cellulose with their physical mixtures in the formulation of folic acid tablets. Pharm Dev Techol. 2002;7:79–87. doi: 10.1081/PDT-120002233. [PubMed] [Cross Ref]
4. Shangraw RF. Direct Compression Tableting. In: Swarbrick J, Boylan JC, editors. Encyclopedia of Pharmaceutical Technology. New York, BY: Marcel Dekker Inc; 1991. pp. 85–106.
5. Sherwood BE, Becker JW. A new class of high-functionality excipients silicified microcrystalline cellulose. Pharm Tech. 1998;October:78–78.
6. United States Pharmacopoeia Convention . United States Pharmacopoeia 24-National Formulary 19. Rockville, MD: US Pharmacopoeia Convention, Inc; 2000. pp. 2524–2525.
7. Bos CE, Bolhius GK, Doorne HV, Lerk CF. Native starch in tablet formulation: properties on compaction. Pharm Weekbl Sci. 1987;9:274–282. [PubMed]
8. Bos CE, Bolhius GK, Lerk CF, Duineveld CAA. Evaluation of modified RS: a new excipient for direct compression. Drug Dev Ind Pharm. 1992;18:93–106. doi: 10.3109/03639049209043686. [Cross Ref]
9. Bavitz JF, Schwartz JB. Direct compression vehicles: evaluation of some common diluents. D&CI. 1974;114(4):44–44.
10. Schwartz JB, Bavitz JF. Direct compression vehicles: effect of common diluents on compression. D&CI. 1976;118(4):60–64.
11. Ohno S, Ikeda M. Excipient Composition. GB 2172006A. September 10, 1986.
12. Ohno S, Ikeda M. Excipient for Use in Compression Molding and Process of Preparation. US patent 5 028 633. July 2, 1991.
13. Carr RL. Evaluating flow properties of solids. Chem Eng. 1965;28:163–168.

Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists