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AAPS PharmSciTech. 2007 March; 8(1): E94–E99.
Published online 2007 February 16. doi:  10.1208/pt0801013
PMCID: PMC2750448

Improving the tablet characteristics and dissolution profile of ibuprofen by using a novel coprocessed superdisintegrant: A technical note

Summary and Conclusion

The coprocessed superdisintegrant proved to be superior to the physical blend in terms of flow due to size enlargement. Furthermore, the coprocessed superdisintegrant displayed superiority in terms of crushing strength, disintegration time, and drug dissolution. The advantages of the proposed method are easy adaptability in industry and the possibility of bypassing the existing patents in the ereas of quick disintegration and dissolution.

KeyWords: Croscarmellose sodium, crospovidone, coprocessing by dry granulation, dissolution enhancement, ibuprofen

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists