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AAPS PharmSciTech. 2007 March; 8(1): E109–E112.
Published online 2007 February 23. doi:  10.1208/pt0801015
PMCID: PMC2750425

Development of a system for simultaneous dissolution studies and magnetic resonance imaging of water transport in hydrodynamically balanced systems: A technical note

Summary and Conclusions

Without disturbing the observed processes, the MRI methods combined with the dissolution studies provide insight into the phenomena occurring when the dosage form comes into contact with aqueous fluids. The MR images allow one to observe the solvent penetration into the hydrophilic matrix and the hydrogel formation. The data obtained in the MRI studies complement information obtained from the dissolution studies. The analysis of MR images may support the explanation of differences in the drug-releasing or floating properties of HBS.

Keywords: Hydrodynamically balanced systems, HBS, floating dosage forms, magnetic resonance imaging, MRI

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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