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AAPS PharmSciTech. 2005 March; 6(1): E31–E34.
Published online 2005 August 10. doi:  10.1208/pt060107
PMCID: PMC2750408

Effect of humidity on the disintegrant property of α-cellulose, Part II: A technical note


The summary is that the high humidity impaired the disintegrant property of α-cellulose in all 3 tablets tested. Tablets of aspirin, which is the more hygroscopic drug, were also more sensitive to the humidity effect, while tablets of chloroquine phosphate, which is a water-soluble drug, were the least sensitive to the humidity effect. The results permit the conclusion that moisture uptake with subsequent gelling of the α-cellulose is the mechanism of impairment of its disintegrant property. The tablets would not normally be stored under an RH as high as 100%, nevertheless, the results of the accelerated stability study have underscored the need to protect tablets containing α-cellulose as disintegrant from moisture.

Keywords: disintegrant property of α-cellulose, humidity effect, tablet hydration

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Molinari E. Carbohydrates. In: Pope TH, editor. Treatise on General and Industrial Organic Chemistry. 2nd ed. London, UK: J and A Churchill; 1913. pp. 503–519.
2. Okhamafe AO, Igboechi AC, Obaseki TO. Cellulose extracted from groundnut shell and rice husk. I. Preliminary physicochemical characterization. Pharm World J. 1991;8:120–123.
3. Okhamafe AO, Igboechi AC, Ubrufih CE, Akinyemi BO, Ighalo MO. Cellulose extracted from groundnut shell and rice husk. 2. Disintegrant properties. Pharm World J. 1992;1:11–16.
4. Azubuike CP. Some Physicochemical and Diluent Properties of Maize Cob Cellulose in Selected Tablet Formulation. Benin City, Nigeria: University of Benin; 2004.
5. Uhumwangho MU, Okor RS. Anomalous effect of compression pressure on the brittle fracture tendency of α-cellulose tablets. Int J Pharm. 2004;284:69–74. doi: 10.1016/j.ijpharm.2004.07.002. [PubMed] [Cross Ref]
6. Kumar V, Kothari SH, Banker GS. Compression, compaction, and disintegration properties of low crystallinity celluloses produced using different agitation rates during their regeneration from phosphoric acid solutions. AAPS PharmSciTech. 2001;2:E7–E7. doi: 10.1208/pt020207. [PubMed] [Cross Ref]
7. Uhumwangho MU, Okor RS. Effect of humidity on the disintegrant property of α-cellulose Part I.Acta Pol Pharm. In press. [PubMed]
8. Uhumwangho MU. Studies on the Disintegrant Property and Tableting Characteristics of α-cellulose. Benin City, Nigeria: University of Benin; 2004.
9. Itiola OA, Pipel N. Tableting characteristics of metronidazole formulations. Int J Pharm. 1986;31:99–105. doi: 10.1016/0378-5173(86)90218-8. [Cross Ref]
10. Sugita ET, Roger LS, Irwin R. Metrology and calculations. In: Gennaro AR, editor. The Science and Practice of Pharmacy. 19th ed. Easton, Pennsylvania: Mack Publishing Co; 1995. pp. 63–93.
11. Brook DB, Marshall K. Crushing strength of compressed tablets I. Comparison of testers. J Pharm Sci. 1968;57:481–484. doi: 10.1002/jps.2600570326. [PubMed] [Cross Ref]
12. British Pharmacopoeia. London, UK: Her Majesty's Stationery Office; 2002:A234.
13. Okor RS, Iwu-Anyanwu U, Okhamafe AO. Swellability of acrylatemethacrylate—cellulose matrix systems and the effect on solute diffusion rates. J Appl Polym Sci. 1992;44:749–750. doi: 10.1002/app.1992.070440501. [Cross Ref]

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