PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of aapspharmspringer.comThis journalToc AlertsSubmit OnlineOpen Choice
 
AAPS PharmSciTech. 2005 September; 6(3): E458–E463.
Published online 2005 October 22. doi:  10.1208/pt060357
PMCID: PMC2750391

Effects of plantain and corn starches on the mechanical and disintegration properties of paracetamol tablets

Abstract

The effects of plantain starch obtained from the unripe fruit of the plantMusa paradisiaca L. (Musaceae) on the mechanical and disintegration properties of paracetamol tablets have been investigated in comparison with the effects of corn starch BP using a 23 factorial experimental design. The individual and combined effects of nature of starch binder (N), concentration of starch binder (C), and the relative density of tablet (RD) on the tensile strength (TS), brittle fracture index (BFI), and disintegration time (DT) of the tablets were investigated. The ranking of the individual effects on TS was RD>C[dbl greater-than sign]N, on BFI was C[dbl greater-than sign]RD>N and on DT was N>C>RD. The ranking for the interaction effects on TS and DT was N-C[dbl greater-than sign]N-RD>C-RD, while that on BFI was N-C[dbl greater-than sign]C-RD>N-RD. Changing nature of starch from a “low” (plantain starch) to a “high” (corn starch) level, increasing the concentration of starch binding agent from 2.5% to 10.0% wt/wt, and increasing relative density of the tablet from 0.80 to 0.90, led to increase in the values of TS and DT, but a decrease in BFI. Thus, tablets containing plantain starch had lower tensile strength and disintegration time values than those containing corn starch, but showed better ability to reduce the lamination and capping tendency in paracetamol tablet formulation. The interaction between N and C was significantly (P<.001) higher than those between N and RD and between C and RD. There is therefore the need to carefully choose the nature (N) and concentration (C) of starch used as binding agent in tablet formulations to obtain tablets of desired bond strength and disintegration properties. Furthermore, plantain starch could be useful as an alternative binding agent to cornstarch, especially where faster disintegration is required and the problems of lamination and capping are of particular concern.

Keywords: plantain starch, corn starch, binding agent, paracetamol, tensile strength, Brittle fracture index, disintegration time

Full Text

The Full Text of this article is available as a PDF (173K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Esezobo S, Ambujam V. An evaluation of starch obtained from plantain (Musa paradisiaca) as a binder and disintegrant for compressed tablets. J Pharm Pharmacol. 1982;34:761–761.
2. Alebiowu G, Itiola OA, eds. Effects of natural and pregelatinized sorghum, plantain and corn starch binders on the compressional characteristics of paracetamol tablet formulation. Pharm Tech. 2001 (suppl):26–30.
3. Alebiowu G, Itiola OA. Compressional characteristics of native and pregelatinized sorghum, plantain and corn starches and the mechanical properties of their tablets. Drug Dev Ind Pharm. 2002;28:663–672. doi: 10.1081/DDC-120003857. [PubMed] [Cross Ref]
4. Alebiowu G, Itiola OA. The effects of starches on mechanical properties of paracetamol tablet formulations. I Pregelatinization of starch binders. Acta Pharm. 2003;53:231–237. [PubMed]
5. Woolfall RC. An approach to product formulation. Soap Perfum Cosmet (Lond). 1964;37:965–970.
6. Itiola OA. Compressional characteristics of three starches and the mechanical properties of their tablets. Pharm World J. 1991;8:91–94.
7. Itiola OA, Pilpel N. Effects of interacting variables on the disintegration and dissolution of metronidazole tablets. Pharmazie. 1996;51:987–989.
8. Odeku OA, Itiola OA. Effects of interacting variables on the tensile strength and the release properties of paracetamol tablets. Trop J Pharm Res. 2003;2:147–153.
9. Itiola OA, Pilpel N. Tableting characteristics of metronidazole formulations. Int J Pharm. 1986;31:99–105. doi: 10.1016/0378-5173(86)90218-8. [Cross Ref]
10. Odeku OA, Itiola OA. Evaluation of khaya gum as a binder in a paracetamol tablet formulation. Pharm Pharmacol Commun. 1998;4:183–188.
11. Hiestand EN, Wells JE, Poet CB, Ochs JF. Physical processes of tabletting. J Pharm Sci. 1977;66:510–519. doi: 10.1002/jps.2600660413. [PubMed] [Cross Ref]
12. Young AH. Fractionations of starch. In: Whistler RL, DeMiller JN, Pashalls EF, editors. Starch Chemistry and Technology. 2nd ed. London: Academic Press; 1984. pp. 249–283.
13. Itiola OA, Pilpel N. Formulation effects on the mechanical properties of metronidazole formulations. J Pharm Pharmacol. 1991;43:145–147. [PubMed]
14. Fell JT, Newton JM. Determination of tablet strength by the diametral compression test. J Pharm Sci. 1970;59:688–691. doi: 10.1002/jps.2600590523. [PubMed] [Cross Ref]
15. Odeku OA, Itiola OA, Adeniran AA. Effects of yam and corn starches on the mechanical and disintegration properties of paracetamol tablets; Ibadan, Nigeria: Omoade Printing Press; 1998. pp. 193–200.
16. Itiola OA. The effects of interacting variables on the tensile strength of lactose powder and compacts. Polytech J Sci Tech. 1990;1:7–19.

Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists