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AAPS PharmSciTech. 2005 September; 6(3): E367–E371.
Published online 2005 October 14. doi:  10.1208/pt060346
PMCID: PMC2750379

Optimization of tablets containing a high dose of spray-dried plant extract: A technical note

Conclusions

Optimization of CSD and CMC-Na in tablet formulations containing a high dose of SDE fromM ilicifolia was performed by central composite design (CCD) and response surface methodology (RSM). The study demonstrated that CSD affected mainly the hardness and friability, while CMC-Na modified the disintegration times. The optimum formula for minimum disintegration time and friability, and maximum crushing strength, was found to contain 1.2% (wt/wt) of CSD and 5.0% (wt/wt) of CMC-Na. At these conditions, the tablet shows a crushing strength of 107.9 N, a friability of 0.56% (wt/wt), and a maximum disintegration time of 6.8 minutes.

Keywords: Tablets, optimization, central composite design, spray-dried extract, Maytenus ilicifolia

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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