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AAPS PharmSciTech. 2007 June; 8(2): E12–E17.
Published online 2007 April 6. doi:  10.1208/pt0802028
PMCID: PMC2750368

Formulation development and optimization using nanoemulsion technique: A technical note

Summary and Conclusion

Ramipril nanoemulsion formulations were successfully prepared by the spontaneous emulsification method (titration method). Sefsol 218 was selected as the oil phase for the development of the formulation on the basis of the solubility studies. The differences in the droplet size between the formulations selected from the phase diagram was not statistically significant, although the polydispersity was at a minimum for the formulation containing 20% oil, 27% Smix, and 53% vol/vol aqueous phase. The droplet size was found to be 34.5 nm. Therefore, nanoemulsion, a multipurpose technology, can be exploited in drug delivery for poorly soluble drugs. Nanoemulsions have a higher solubilization capacity than simple micellar solutions, and their thermodynamic stability offers advantages over unstable dispersions, such as emulsions and suspensions, because they can be manufactured with little energy input (heat or mixing) and have a long shelf life. This technical note explains the basis for calculation and construction of pseudoternary phase diagrams and, most important, explains selection of the formulations from the phase diagrams to avoid metastable formulations having minimum surfactant concentration in the least possible time.

Keywords: Ramipril, nanoemulsion, pseudoternary phase diagram, thermodynamic stability, solubility, droplet size

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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