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AAPS PharmSciTech. 2006 December; 7(4): E24–E30.
Published online 2014 March 30. doi:  10.1208/pt070486
PMCID: PMC2750323

The effect of drug concentration and curing time on processing and properties of calcium alginate beads containing metronidazole by response surface methodology

Abstract

The purpose of present research work was to prepare calcium alginate beads containing water-soluble drug metronidazole using 32 factorial design, with drug concentration and curing time as variables. Curing time was kept as low as possible to improve entrapment with increasing drug concentration. Mostly the drugs which had been encapsulated were water insoluble to facilitate drug encapsulation; a characteristic drug release as whole process is aqueous based. Entrapment efficiency was in the range of 81% to 96% wt/wt, which decreased with decrease in polymer concentration and increase in curing time. The beads were spherical with size range between 1.4 and 1.9 mm. Scanning electron microscope (SEM) photomicrographs revealed increase in the leaching of drug crystals with increased curing time and high drug concentrations. In acidic environment, the swelling ratio was 200% in 30 minutes, but in basic medium, it increased to a maximum of 1400% within 120 minutes. In acidic medium, the swelling and drug release properties were influenced by drug solubility, whereas in phosphate buffer these properties were governed by the gelling of polymer and exhibited curvilinear and quadratic functions of both the variables, respectively.

Keywords: calcium alginate, ionotropic gelling, water-soluble drug, curing time, metronidazole

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Shilpa A, Agrawal SS, Rao AR. Controlled delivery of drugs from alginate matrix. J Macromol Sci-Polym Rev. 2003;43:187–221. doi: 10.1081/MC-120020160. [Cross Ref]
2. Draget KI, Skjak-Braek G, Smidsrod O. Alginate based new materials. Int J Biol Macromol. 1997;21:47–55. doi: 10.1016/S0141-8130(97)00040-8. [PubMed] [Cross Ref]
3. Tomida H, Mizuo C, Nakamura C, Kiryu S. Imipramine release from Ca-alginate gel beads. Chem Pharm Bull (Tokyo) 1993;41:1475–1477. doi: 10.1248/cpb.41.1475. [Cross Ref]
4. Lim LY, Wan LSC. Propranolol hydrochloride binding in calcium alginate beads. Drug Dev Ind Pharm. 1997;23:973–980. doi: 10.3109/03639049709149149. [Cross Ref]
5. Batchelor HK, Banning D, Dettmar PW, Hampson FC, Jolliffe IJ, Craig DQM. An in-vitro mucosal model for the prediction of the bioadhesion of alginate solutions to the oesophagus. Int J Pharm. 2002;238:123–132. doi: 10.1016/S0378-5173(02)00062-5. [PubMed] [Cross Ref]
6. Blandino A, Macias M, Cantero D. Glucose oxidase release from calcium alginate gel capsules. Enzyme Microb Technol. 2000;27:319–324. doi: 10.1016/S0141-0229(00)00204-0. [PubMed] [Cross Ref]
7. Bodmeier R, Paeratakul O. Spherical agglomerates of water-insoluble drugs. J Pharm Sci. 1989;78:964–967. doi: 10.1002/jps.2600781117. [PubMed] [Cross Ref]
8. Bodmeier R, Wang J. Microencapsulation of drugs with aqueous colloidal polymer dispersions. J Pharm Sci. 1993;82:191–194. doi: 10.1002/jps.2600820215. [PubMed] [Cross Ref]
9. Takka S, Ocak OH, Acarturk F. Formulation and investigation of nicardipine HCl-alginate gel beads with factorial design-based studies. Eur J Pharm Sci. 1998;6:241–246. doi: 10.1016/S0928-0987(97)10005-7. [PubMed] [Cross Ref]
10. Yotsuyanagi T, Ohkubo T, Ohhashi T, Ikeda T. Calcium-induced gelation of alginic acid and pH-sensitive reswelling of dried gels. Chem Pharm Bull (Tokyo) 1987;35:1555–1563. doi: 10.1248/cpb.35.1555. [Cross Ref]
11. Kulkarni AR, Soppimath KS, Aminabhavi TM. Controlled release of diclofenac sodium from sodium alginate beads crosslinked with glutaraldehyde. Pharm Acta Helv. 1999;74:29–36. doi: 10.1016/S0031-6865(99)00015-1. [Cross Ref]
12. Acarturk F, Takka S. Calcium alginate microparticles for oral administration. II. Effect of formulation factors on drug release and drug entrapment efficiency. J Microencapsul. 1999;16:275–290. doi: 10.1080/026520499289013. [PubMed] [Cross Ref]
13. Murata Y, Sasaki N, Miyamoto E, Kawashima S. Use of floating alginate gel beads for stomach-specific drug delivery. Eur J Pharm Biopharm. 2000;50:221–226. doi: 10.1016/S0939-6411(00)00110-7. [PubMed] [Cross Ref]
14. Efentakis M, Buckton G. The effect of erosion and swelling on the dissolution of Theophylline from low and high viscosity sodium alginate matrices. Pharm Dev Technol. 2002;7:69–77. doi: 10.1081/PDT-120002232. [PubMed] [Cross Ref]
15. Fundueanu G, Mihai D, Carpov A, Desbrieres J, Rinaudo M, Nastruzzi C. Preparation and characterization of Ca-alginate microspheres produced with different methods. Biomaterials. 1999;20:1427–1435. doi: 10.1016/S0142-9612(99)00050-2. [PubMed] [Cross Ref]

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