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AAPS PharmSciTech. 2003 March; 4(1): 1–5.
Published online 2003 January 9. doi:  10.1208/pt040101
PMCID: PMC2750297

Synergistic effect of PEG-400 and cyclodextrin to enhance solubility of progesterone


PEG-400, polysorbate 80, and 2 CDs (Trappsol HPB and Captisol) were used in an attempt to improve the aqueous solubility of a model hydrophobic drug, progesterone. The aqueous solubility of progesterone improved significantly from 0.007 mg/mL by the addition of PEG-400, CDs, and polysorbate 80. In systems containing various amounts of PEG-400 and 3% Trappsol HPB in water (% wt/wt), the theoretical solubility was calculated by adding the solubilities in the individual systems. The observed solubility values were up to 96% higher than the theoretical values. The effect of synergism was significant in 5% to 50% PEG-400/water systems containing Trappsol HPB. Systems containing Captisol did not show such synergistic effects. In general, the addition of polysorbate 80 to the PEG-400/water systems containing CDs affected synergism negatively.

Keywords: cosolvent, cyclodextrins, PEG-400, progesterone, solubilization, synergism

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Selected References

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