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AAPS PharmSciTech. 2006 June; 7(2): E95–E98.
Published online 2006 May 12. doi:  10.1208/pt070244
PMCID: PMC2750295

Viscoelastic properties of a virucidal cream containing the monoglyceride monocaprin: Effects of formulation variables: A technical note

Summary and Conclusions

The viscoelastic properties of the cream formulations were tested by 2 methods (ie, increased stress and increased frequency tests). The rheology experiments indicate that the formulations are stable; they show resistance to external forces, as their elastic properties are sustained whether or not the magnitude or frequency of external forces are increased. The results show that rheological properties of the formulations are affected by the proportion of the oil phase and the amount of carbomer in the aqueous phase, but the effect of monocaprin is modest. Increasing carbomer amount increases viscosity and elasticity. Increasing the oil volume fraction increased the structural stability of the creams. The formulation containing monocaprin, which yielded the most viscoelastic structure was a cream containing 10% oil phase and 0.5% carbomer (Formulation 9).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
1. Tadros TF. Fundamental Principles of Emulsion Rheology and Their Applications. Colloids Surf A Physicochem Eng Aspects. 1994;91:39–55. doi: 10.1016/0927-7757(93)02709-N. [Cross Ref]
2. Korhonen M, Niskanen H, Kiesvaara J, Yliruusi J. Determination of optimal combination of surfactants in creams using rheology measurements. Int J Pharm. 2000;197:143–151. doi: 10.1016/S0378-5173(99)00464-0. [PubMed] [Cross Ref]
3. Martin A. Physical Pharmacy. London, UK: Lea & Febiger; 1993.
4. Gasperlin M, Tusar L, Tusar M, Kristl J, Smid-Korbar J. Lipophilic semisolid emulsion systems: viscoelastic behaviour and prediction of physical stability by neural network modelling. Int J Pharm. 1998;168:243–254. doi: 10.1016/S0378-5173(98)00099-4. [Cross Ref]
5. Thormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob Agents Chemother. 1987;31:27–31. [PMC free article] [PubMed]
6. Thormar H, Bergsson G, Gunnarsson E, et al. Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro. Sex Transm Infect. 1999;75:181–185. doi: 10.1136/sti.75.3.181. [PMC free article] [PubMed] [Cross Ref]
7. Bergsson G, Steingrimsson O, Thormar H. Bactericidal effects of fatty acids and monoglycerides on Helicobacter pylori. Int J Antimicrob Agents. 2002;20:258–262. doi: 10.1016/S0924-8579(02)00205-4. [PubMed] [Cross Ref]
8. Kristmundsdottir T, Arnadottir SG, Bergsson G, Thormar H. Development and evaluation of microbicidal hydrogels containing monoglyceride as the active ingredient. J Pharm Sci. 1999;88:1011–1015. doi: 10.1021/js9900396. [PubMed] [Cross Ref]
9. Thorgeirsdottir TO, Thormar H, Kristmundsdottir T. Effects of polysorbates on antiviral and antibacterial activity of monoglyceride in pharmaceutical formulations. Pharmazie. 2003;58:286–287. [PubMed]
10. Thorgeirsdottir TO, Hilmarsson H, Thormar H, Kristmundsdottir T. Development of a virucidal cream containing the monoglyceride monocaprin. Pharmazie. 2005;60:897–899. [PubMed]
11. Thorgeirsdottir TO, Thormar H, Kristmundsdottir J. The influence of formulation variables on stability and microbicidal activity of monoglyceride monocaprin. J Drug Del Sci Techn. 2005;15:233–236.

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