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AAPS PharmSciTech. 2006 June; 7(2): E122–E125.
Published online 2006 May 26. doi:  10.1208/pt070248
PMCID: PMC2750275

Spherical agglomeration of mefenamic acid and nabumetone to improve micromeritics and solubility: A technical note

Summary and Conclusions

Spherical agglomeration techniques were developed for improving the flow and compressibility characteristics of microcrystalline mefenamic acid and nabumetone. The process involved agglomerating microcrystals using agglomerating solvents. Temperature and speed of agitation were optimized to obtain spherical agglomerates in a desired range, which was found to be essential to enhance compressibility. Incorporation of polymer HPMC during agglomeration significantly enhanced the dissolution rate of mefenamic acid while incorporation of solubilizing agent lecithin improved the solubility of nabumetone. Thus, spherical agglomeration is an important technique for improving direct compressibility of pharmaceutical powders and is especially useful when the drug dosage is high.

Keywords: spherical crystallization, mefenamic acid, nabumetone, micromeritics, spherical agglomeration

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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Articles from AAPS PharmSciTech are provided here courtesy of American Association of Pharmaceutical Scientists