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AAPS PharmSciTech. 2001 March; 2(1): 34–52.
Published online 2001 March 23. doi:  10.1208/pt020104
PMCID: PMC2750258

Evaluation of preseparator performance for the 8-stage nonviable Andersen impactor

Abstract

The preseparator of an Andersen impactor with different coating treatments for a range of particle-size distributions was evaluated. Limited theoretical simulations constrained by simplifying assumptions of the airflow fields in the preseparator and upper stages of an 8-stage Andersen impactor were used to reveal low-velocity and high-pressure regions for potential deposition. These regions were then sampled in subsequent particle deposition experiments. Disodium fluorescein aerosols were sampled with different coating treatments of the preseparator floor. Particles collected at impactor stages determined particle size distributions. Stage deposition was compared between different preseparator treatments (buffer and silicon oil). Collection efficiency in the preseparator followed the pattern buffer >silicon oil >untreated. Statistical differences (P>0.05) were noted in collection efficiency of large particles (45 μm-75 μm) in the preseparator. The mass median aerodynamic diameters and geometric standard deviations showed some statistical differences when different preseparator treatments for large particles were used; therefore, preseparator coating was shown to influence performance and thereby estimates of particle size by intertial impaction.

Keywords: Inertial impaction, Preseparator, Wall losses, Finite element analysis

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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