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Testing for carcinogenic or high-risk human papillomavirus (HPV) DNA has proven utility in cervical cancer screening and in many aspects of clinical management for cervical cancer prevention. However, inappropriate testing increases costs without benefit and potentially results in over-treatment of women. This Statement was developed by the Cytopathology and Technology Education Consortium and has been endorsed by additional professional medical societies as listed below. It is intended as a concise, convenient summary of clinical indications for HPV DNA test utilization based on the American Cancer Society 2002 screening recommendations1 and interim guidance2, and the 2006 American Society for Colposcopy and Cervical Pathology (ASCCP) consensus management guidelines3. Circumstances in which HPV DNA testing is considered appropriate, and when such testing is generally not appropriate, are outlined below. This statement is intended to serve an educational tool and reference to improve management of women and reduce inappropriate use of HPV tests.
Endorsed by the:
American Cancer Society
#American Society for Clinical Pathology
American Society for Colposcopy and Cervical Pathology
#American Society of Cytopathology
#American Society for Cytotechnology
#College of American Pathologists
#International Academy of Cytology
#Papanicolaou Society of Cytopathology
# Indicates member of the Cytopathology Education and Technology Consortium
The intent of this summary is to facilitate provider education and to encourage appropriate utilization of HPV testing. Clinical judgment should always be used when applying a guideline to an individual patient because it is impossible to develop guidelines that apply to all situations. Links to the 2006 ASCCP Consensus Guidelines, as well as management algorithms, are available on the ASCCP website at http://www.asccp.org/consensus/cytological.shtml.
*Note that for AGC results, HPV testing is not to be used for triage to decide whether to refer to colposcopy; however HPV testing may be done at the time of colposcopy to guide post-colposcopy management.