In the U.S., opioid dependence continues to increase (1). To address this increasing need for treatment of opioid dependence, buprenorphine can now be prescribed in primary care settings. Despite this, buprenorphine treatment in primary care is limited, and treatment of opioid dependence remains inadequate (2–3). Although there are many reasons why administrators and physicians are reluctant to offer buprenorphine treatment (2, 4), two particular reasons may include concern about becoming overwhelmed with opioid-dependent patients and attracting patients from outside of the neighborhood that a health center serves. Few studies describe buprenorphine treatment experiences in primary care, and none describe patterns of new inquiries and treatment initiation over time. We document inquiries about and initiation of buprenorphine treatment in an inner-city health center.