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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
Am J Prev Med. Author manuscript; available in PMC 2010 July 1.
Published in final edited form as:
Am J Prev Med. 2009 July; 37(1 Suppl): S71–S77.
doi: 10.1016/j.amepre.2009.04.008

Table 4

Sensitivity, specificity, and PPV of TC, LDL-C, HDL-C, and TGs screening, by race/ethnic groupa

Lipid testScreening criterionSensitivity (CI)Specificity (CI)PPV (CI)
Nonblacks
 TC ≥90th percentileFamily history0.402 (0.307, 0.497)0.611 (0.566, 0.657)0.193 (0.140, 0.247)
 LDL-C ≥90th percentileFamily history0.436 (0.326, 0.546)0.616 (0.572, 0.661)0.160 (0.111, 0.210)
 HDL-C <10th percentileFamily history0.507 (0.389, 0.625)0.626 (0.582, 0.667)0.165 (0.115, 0.215)
 TGs ≥90th percentileFamily history0.445 (0.367, 0.523)0.630 (0.582, 0.679)0.325 (0.262, 0.389)
 TC ≥90th percentileBMI ≥85th percentile0.314 (0.224, 0.404)0.798* (0.760, 0.835)0.264 (0.186, 0.343)
 LDL-C ≥90th percentileBMI ≥85th percentile0.333 (0.229, 0.438)0.795* (0.759, 0.832)0.215 (0.142, 0.288)
 HDL-C <10th percentileBMI ≥85th percentile0.391 (0.276, 0.506)0.801* (0.765, 0.837)0.223a (0.149, 0.297)
 TGs ≥90th percentileBMI ≥85th percentile0.355 (0.280, 0.430)0.829* (0.792, 0.867)0.455 (0.366, 0.543)
 TC ≥90th percentileBMI ≥85th percentile or family history0.539* (0.442, 0.636)0.477* (0.431, 0.524)0.193 (0.147, 0.239)
 LDL-C ≥90th percentileBMI ≥85th percentile or family history0.603* (0.494, 0.711)0.487* (0.442, 0.533)0.165 (0.122, 0.208)
 HDL-C <10th percentileBMI ≥85th percentile or family history0.681* (0.571, 0.791)0.497* (0.452, 0.542)0.165 (0.122, 0.208)
 TGs ≥90th percentileBMI ≥85th percentile or family history0.606* (0.530, 0.683)0.506* (0.457, 0.556)0.330 (0.275, 0.384)
Blacks
 TC ≥90th percentileFamily history0.263 (0.065, 0.461)0.784 (0.710, 0.859)0.167 (0.033, 0.300)
 LDL-C ≥90th percentileFamily history0.286 (0.049, 0.522)0.785 (0.712, 0.858)0.133 (0.012, 0.255)
 HDL-C <10th percentileFamily history0.182 (0.021, 0.343)0.770 (0.692, 0.848)0.133 (0.012, 0.255)
 TGs ≥90th percentileFamily history0.350 (0.141, 0.559)0.800 (0.727, 0.873)0.233 (0.082, 0.385)
 TC ≥90th percentileBMI ≥85th percentile0.474 (0.249, 0.698)0.733 (0.652, 0.813)0.225 (0.096, 0.354)
 LDL-C ≥90th percentileBMI ≥85th percentile0.643 (0.392, 0.894)0.744 (0.666, 0.822)0.225 (0.096, 0.354)
 HDL-C <10th percentileBMI ≥85th percentile0.545* (0.337, 0.754)0.752 (0.673, 0.832)0.300 (0.158, 0.442)
 TGs ≥90th percentileBMI ≥85th percentile0.550 (0.332, 0.768)0.748 (0.668, 0.827)0.275 (0.137, 0.413)
 TC ≥90th percentileBMI ≥85th percentile or family history0.526 (0.302, 0.751)0.578* (0.488, 0.667)0.169 (0.074, 0.265)
 LDL-C ≥90th percentileBMI ≥85th percentile or family history0.643 (0.392, 0.894)0.587* (0.499, 0.675)0.153 (0.061, 0.244)
 HDL-C <10th percentileBMI ≥85th percentile or family history0.591* (0.385, 0.796)0.593* (0.502, 0.684)0.220 (0.115, 0.326)
 TGs ≥90th percentileBMI ≥85th percentile or family history0.750* (0.560, 0.940)0.617* (0.529, 0.706)0.254 (0.143, 0.365)
*Significant at p<0.05; differences in sensitivity, specificity, and PPV between using family as a screening criterion and using BMI ≥85th percentile alone or family history and BMI ≥85th percentile together were examined.
aFamily history=family history of cardiovascular disease (parental history of high blood pressure, high cholesterol, heart attack, and stroke; or parent or grandparent who died from cardiovascular or cerebrovascular diseases when aged <55 years)

HDL-C, high-density lipoprotein cholesterol, LDL-C, low-density lipoprotein cholesterol; PPV, positive predictive value; TC, total cholesterol; TGs, triglycerides