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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
Am J Prev Med. Author manuscript; available in PMC 2010 July 1.
Published in final edited form as:
Am J Prev Med. 2009 July; 37(1 Suppl): S71–S77.
doi: 10.1016/j.amepre.2009.04.008

Table 3

Sensitivity, specificity, and PPV of TC, LDL-C, HDL-C, and TGs screening by gender groupsa

Lipid testScreening criterionSensitivity (CI)Specificity (CI)PPV (CI)
Boys
 TC ≥90th percentileFamily history0.351 (0.244, 0.457)0.672 (0.615, 0.728)0.235 (0.157, 0.312)
 LDL-C ≥90th percentileFamily history0.368 (0.243, 0.494)0.634 (0.619, 0.728)0.183 (0.112, 0.253)
 HDL-C <10th percentileFamily history0.453 (0.319, 0.587)0.688 (0.635, 0.741)0.209 (0.134, 0.283)
 TGs ≥90th percentileFamily history0.439 (0.345, 0.533)0.714 (0.657, 0.772)0.409 (0.319, 0.499)
 TC ≥90th percentileBMI ≥85th percentile0.364 (0.256, 0.471)0.787* (0.738, 0.836)0.329 (0.229, 0.429)
 LDL-C ≥90th percentileBMI ≥85th percentile0.386 (0.260, 0.512)0.781* (0.734, 0.829)0.259 (0.166, 0.352)
 HDL-C <10th percentileBMI ≥85th percentile0.472 (0.337, 0.606)0.795* (0.748, 0.841)0.294 (0.197, 0.391)
 TGs ≥90th percentileBMI ≥85th percentile0.393 (0.300, 0.485)0.819* (0.770, 0.868)0.494 (0.387, 0.600)
 TC ≥90th percentileBMI ≥85th percentile or family history0.506* (0.395, 0.618)0.504* (0.444, 0.564)0.227 (0.164, 0.289)
 LDL-C ≥90th percentileBMI ≥85th percentile or family history0.561* (0.433, 0.690)0.514* (0.456, 0.572)0.186 (0.128, 0.244)
 HDL-C <10th percentileBMI ≥85th percentile or family history0.679* (0.554, 0.805)0.534* (0.477, 0.591)0.209 (0.149, 0.270)
 TGs ≥90th percentileBMI ≥85th percentile or family history0.636* (0.544, 0.727)0.563* (0.500, 0.626)0.395 (0.322, 0.468)
Girls
 TC ≥90th percentileFamily history0.432 (0.285, 0.578)0.625 (0.569, 0.681)0.150 (0.088, 0.212)
 LDL-C ≥90th percentileFamily history0.486 (0.320, 0.651)0.630 (0.575, 0.685)0.134 (0.075, 0.193)
 HDL-C <10th percentileFamily history0.395 (0.239, 0.550)0.619 (0.564, 0.675)0.118 (0.062, 0.174)
 TGs ≥90th percentileFamily history0.426 (0.309, 0.544)0.629 (0.571, 0.687)0.228 (0.155, 0.301)
 TC ≥90th percentileBMI ≥85th percentile0.295 (0.161, 0.430)0.781* (0.734, 0.829)0.171 (0.086, 0.256)
 LDL-C ≥90th percentileBMI ≥85th percentile0.371 (0.211, 0.532)0.788* (0.741, 0.834)0.171 (0.086, 0.256)
 HDL-C <10th percentileBMI ≥85th percentile0.368 (0.215, 0.522)0.789* (0.742, 0.836)0.184 (0.097, 0.271)
 TGs ≥90th percentileBMI ≥85th percentile0.353 (0.239, 0.467)0.803* (0.755, 0.851)0.316 (0.211, 0.420)
 TC ≥90th percentileBMI ≥85th percentile or family history0.591* (0.446, 0.736)0.493* (0.435, 0.551)0.151 (0.098, 0.205)
 LDL-C ≥90th percentileBMI ≥85th percentile or family history0.686* (0.532, 0.840)0.502* (0.445, 0.559)0.140 (0.088, 0.191)
 HDL-C <10th percentileBMI ≥85th percentile or family history0.632* (0.478, 0.785)0.497* (0.439, 0.554)0.140 (0.088, 0.191)
 TGs ≥90th percentileBMI ≥85th percentile or family history0.603* (0.487, 0.719)0.504* (0.443, 0.564)0.238 (0.175, 0.302)
*Significant at p<0.05; differences of sensitivity, specificity, and PPV between using family history as a screening criterion and using (BMI ≥85th percentile) or (family history or BMI ≥85th percentile) were examined.
aFamily history=family history of cardiovascular disease (parental history of high blood pressure, high cholesterol, heart attack, and stroke; or parent or grandparent who died from cardiovascular or cerebrovascular diseases when aged <55 years)

HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; PPV, positive predictive value; TC, total cholesterol; TGs, triglycerides