Effects of insulin on body temperature effects of a low MDMA dose (5 mg/kg, sc). Insulin (10 units/kg, sc) was administered 15 min. before MDMA. Glucose (1 g/kg, ip) was administered 15 min. after MDMA. Each point represents the mean ± S.E.M. (n=6). *Indicates significantly different from all other treatment groups (P<0.001); **indicates significantly different from normal saline (NS)-NS only (P<0.01); and ^indicates significantly different from NS-NS and insulin-glucose-MDMA (P<0.05).