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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Lancet. Author manuscript; available in PMC 2010 August 15.
Published in final edited form as:
PMCID: PMC2728138
NIHMSID: NIHMS117182

Treatments for nicotine addiction should be a top priority

Cigarette smoking is a leading cause of death in the USA. The practice has been linked to 440 000 preventable deaths per year, mainly due to lung cancer (123 836), coronary heart disease (86 801), and respiratory disease and chronic obstructive pulmonary disease (90 582).1,2 These deaths are the outcome of nicotine addiction, which compels individuals to use tobacco despite the known adverse health consequences. Sadly, priorities for investment in clinical trials are directed at treatment of diseases caused by continued tobacco use, rather than addressing the root cause of the diseases: nicotine addiction (figure). Moreover, clinical trials for smoking cessation and treatment of nicotine addiction are not even within the top 25 therapeutic categories in development by the drug industry; anticancer treatments are the first priority.3 174 pharmacotherapy trials were done for smoking cessation (46 supported by industry) com pared with 1490 for lung cancer (544 supported by industry).

Figure
Research priorities in tobacco addiction

The small number of trials for smoking cessation does not correspond to absence of demand. Many smokers would try to quit smoking if effective and inexpensive approaches were available. Of 45·3 million US adult smokers, 43·5% had tried to quit in the past 12 months, and 80% of those who attempted to quit on their own, without pharma cological or behavioural therapies, relapsed within the first month, with only 3% still abstinent at 6 months.4

Unless budgets are increased to develop effective treatments for tobacco dependence, and to make these treatments available to an increased number of people, the Healthy People 2010 goal5 to reduce the proportion of US tobacco users from 21% to 12% is unlikely to be met. According to current projections, 16% of the US population—35 million people—will still smoke in 2025. Although the proportion of people that successfully quit smoking increased between 1965 (13·6%) and 1985 (24·2%), the proportion has since remained fairly constant, and existing smokers are more severely addicted than they were in the past.1,6,7 Furthermore, the effect of available drugs is small, with only 15–35% of individuals using pharmacotherapy able to remain abstinent for more than a year. Investment in the development of new treatments for smoking cessation will save lives and reduce the huge costs of related diseases (about US$181 billion).1

Despite enormous efforts to fi nd treatments for lung cancer, the 5-year survival rate has increased from 6% to only 14%, and incidence and mortality have increased 2·5-fold during the same period.8 Incorporation of tobacco dependence into a conceptual model of chronic disease will be of profound and immediate benefit to public health. Furthermore, research findings should be used to identify new molecular targets for nicotine addiction and biomarkers to predict treatment success.

Footnotes

We declare that we have no conflicts of interest.

References

1. Bonnie RJ, Stratton K, Wallace RB, editors. Ending the tobacco problem: a blueprint for the nation. National Academies Press; Washington, DC: 2007.
2. Centers for Disease Control and Prevention Annual smoking-attributable mortality, years of potential life lost, and productivity losses—United States, 1997-2001. MMWR Morb Mortal Wkly Rep. 2005;54:625–28. [PubMed]
3. Informa Healthcare Therapy analysis—pharma R&D annual review. May, 2007. http://www.pharmaprojects.com/therapy_analysis/annual-review-0508-therapeutic-areas.htm (accessed March 13, 2009)
4. Shiffman S, Brockwell SE, Pillitteri JL, Gitchell JG. Use of smoking-cessation treatments in the United States. Am J Prev Med. 2008;34:102–11. [PubMed]
5. US Department of Health and Human Services . Tobacco use. 2nd edn Vol. 2. US Government Printing Office; Washington, DC: 2000. Healthy People 2010.
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7. Centers for Disease Control and Prevention Smoking and tobacco use. Percentage of adults who were current, former, or never smokers, overall and by sex, race, Hispanic origin, age, education, and poverty status. 1965–2006. http://www.cdc.gov/tobacco/data_statistics/tables/adult/table_2.htm (accessed March 13, 2009)
8. Welch HG, Schwartz LM, Woloshin S. Are increasing 5-year survival rates evidence of success against cancer? JAMA. 2000;283:2975–78. [PubMed]