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Table II

Association between maternal anxiety symptoms at 18 weeks and 32 weeks of gestation and asthma in children age 7½ years

OR (95% CI) for asthma at 7½ y
OR (95% CI) for asthma with BHR
N asthma/no asthma (% with asthma)CrudeAdjusted*N asthma/no asthma (% with asthma)CrudeAdjusted*
Maternal anxiety at 18 wk
 1st quartile (0-2)198/1734 (10.2%)1 (reference)1 (reference)38/1734 (2.1%)1 (reference)1 (reference)
 2nd quartile (3-4)174/1176 (12.9%)1.30 (1.04-1.61)1.24 (1.00-1.55)33/1176 (2.7%)1.28 (0.80-2.05)1.22 (0.76-1.97)
 3rd quartile (5-7)200/1295 (13.4%)1.35 (1.10-1.67)1.32 (1.07-1.63)29/1295 (2.2%)1.02 (0.63-1.67)0.99 (0.60-1.62)
 4th quartile (8-16)163/870 (15.8%)1.64 (1.31-2.05)1.53 (1.22-1.93)24/870 (2.7%)1.26 (0.75-2.11)1.24 (0.73-2.11)
 P (trend)<.001<.001.6.6
Maternal anxiety at 32 wk
 1st quartile (0-2)168/1582 (9.6%)1 (reference)1 (reference)27/1582 (1.7%)1 (reference)1 (reference)
 2nd quartile (3-4)185/1232 (13.1%)1.41 (1.13-1.77)1.36 (1.09-1.71)29/1232 (2.3%)1.38 (0.81-2.34)1.35 (0.79-2.30)
 3rd quartile (5-7)204/1308 (13.5%)1.47 (1.18-1.82)1.42 (1.14-1.77)35/1308 (2.6%)1.57 (0.94-2.60)1.55 (0.93-2.58)
 4th quartile 8-16)178/953 (15.7%)1.76 (1.40-2.20)1.65 (1.30-2.08)33/953 (3.3%)2.03 (1.21-3.40)2.09 (1.24-3.53)
 P (trend)<.001<.001.006.005
*Adjusted for sex, preterm delivery, multiple birth, number of siblings, maternal age, maternal education, maternal history of asthma and allergy, prenatal tobacco smoke exposure, and problems during pregnancy (diabetes, hypertension, steroid intake).