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Table I

Comparison of population with complete data with those with incomplete data or lost to follow-up

Original cohort N = 10,710Study population N = 5,810*Incomplete N = 4,900P value
Prenatal measures
Main exposures
 Maternal anxiety at 18 wk
  1st quartile (0-2)3,265 (30.5)1,932 (33.3)1,333 (27.2)
  2nd quartile (3-4)2,411 (22.5)1,350 (23.2)1,061 (21.7)<.001
  3rd quartile (5-7)2,814 (26.3)1,495 (25.7)1,319 (26.9)
  4th quartile (8-16)2,220 (20.7)1,033 (17.8)1,187 (24.2)
 Maternal anxiety at 32 wk
  1st quartile (0-2)2,981 (27.8)1,750 (30.1)1,231 (25.1)
  2nd quartile (3-4)2,481 (23.2)1,417 (24.4)1,064 (21.7)<.001
  3rd quartile (5-7)2,836 (26.5)1,512 (26.0)1,324 (27.0)
  4th quartile (8-16)2,412 (22.5)1,131 (19.5)1,281 (26.1)
Confounders
 Maternal age (mean [SD])28.4 (4.8)29.2 (4.5)27.4 (5.0)<.001
 Low birth weight <2.5 kg498/10,577 (4.7)247 (4.3)251/4,767 (5.3).01
 Sex (males)5,539/10,709 (51.7)2,985 (51.4)2,554/4,899 (52.1).4
 Preterm <37 wk599 (5.6)296 (5.1)303 (6.2).02
 Multiple birth283 (2.6)136 (2.3)147 (3.0).03
 ≥1 Sibling5,862/10,603 (55.3)3,127 (53.8)2,735/4,793 (57.1).001
 Maternal low education6,822/10,657 (64.0)3,343 (57.5)3,479/4,847 (71.8)<.001
 Maternal asthma1,166/10,265 (11.4)610 (10.5)556/4,455 (12.5).002
 Maternal allergy4,411/10,224 (43.1)2,551 (43.9)1,860/4,414 (42.1).07
 Maternal smoking in pregnancy3,459 (32.3)1,505 (25.9)1,954 (39.9)<.001
 Diabetes during pregnancy52 (0.5)30 (0.5)22 (0.4).6
 Hypertension during pregnancy1,031 (9.6)529 (9.1)502 (10.2).05
 Steroids during pregnancy60 (0.6)29 (0.5)31 (0.6).4
Other exposures
 Partner's anxiety at 18 wkN = 8,139N = 4,688N = 3,451
  1st quartile (0-1)3,089 (38.0)1,778 (37.9)1,311 (38.0)
  2nd quartile (2)1,341 (16.5)752 (16.0)589 (17.1).6
  3rd quartile (3-4)1,744 (21.4)1,011 (21.6)733 (21.2)
  4th quartile (5-16)1,965 (24.1)1,147 (24.5)818 (23.7)
Postnatal measures
Main outcomes
 Current asthma at 7½ y781/6,129 (12.7)735/5,810 (12.7)46/319 (14.4).4
 Current asthma with bronchial hyperresponsiveness130/5,478 (2.4)124/5,199 (2.4)6/279 (2.2).8
 Atopic asthma285/5,596 (5.1)271/5,303 (5.1)14/293 (4.9).9
 Nonatopic asthma248/5,633 (4.4)228/5,346 (4.3)20/287 (6.8).04
Other exposures
 Maternal anxiety at 8 moN = 9,412N = 5,543N = 3,869
  1st quartile (0-1)3,087 (32.8)1,864 (33.6)1,223 (31.6)
  2nd quartile (2-3)2,689 (28.6)1,615 (29.1)1,074 (27.8).001
  3rd quartile (4-5)1,590 (16.9)933 (16.8)657 (17.0)
  4th quartile (6-16)2,046 (21.7)1,131 (20.4)915 (23.6)
 Maternal depression at 8 moN = 9,421N = 5552N = 3,869
  1st quartile (0-2)3,147 (33.4)1,918 (34.5)1,229 (31.8)
  2nd quartile (3-4)1,780 (18.9)1,083 (19.5)697 (18.0)<.001
  3rd quartile (5-8)2,504 (26.6)1,472 (26.5)1,032 (26.7)
  4th quartile (9-29)1,990 (21.1)1,079 (19.4)911 (23.5)
 Children's internalizing symptomsN = 8,046N = 5,312N = 2,734
  1st tertile (0-1)4,940 (61.4)3,284 (61.8)1,656 (60.6)
  2nd tertile (2)1,457 (18.1)959 (18.1)498 (18.2).5
  3rd tertile (3-10)1,649 (20.5)1,069 (20.1)580 (21.2)

n/N (%) corresponds to number of positive cases, total, and percentage (N as specified in column heading when not indicated).

*Children with data on maternal anxiety symptoms at both 18 and 32 weeks of gestation, current asthma at 7½ years, and all confounders.
Full time education up to and including General Certificate of Education (equivalent to school leaving certificate at age 16 y).
P value for t test for comparison of means or χ2 test for comparison of proportions.