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Associations between maternal anxiety symptoms at 18 and 32 weeks of gestation and asthma with atopy in children age 7½ years
OR (95% CI) for atopic asthma at 7½ y
OR (95% CI) for nonatopic asthma at 7½ y
N asthma/no asthma (% with asthma)CrudeAdjusted*N asthma/no asthma (% with asthma)CrudeAdjusted*
Maternal anxiety at 18 wk
 1st quartile (0-2)80/1734 (4.4%)1 (reference)1 (reference)66/1734 (3.7%)1 (reference)1 (reference)
 2nd quartile (3-4)72/1176 (5.8%)1.33 (0.96-1.84)1.27 (0.91-1.77)42/1176 (3.4%)0.94 (0.63-1.39)0.92 (0.62-1.37)
 3rd quartile (5-7)68/1295 (5%)1.14 (0.82-1.59)1.11 (0.79-1.56)58/1295 (4.3%)1.18 (0.82-1.69)1.17 (0.81-1.68)
 4th quartile 8-16)51/870 (5.5%)1.27 (0.89-1.82)1.20 (0.83-1.74)62/870 (6.7%)1.87 (1.31-2.67)1.78 (1.24-2.57)
 P (trend).3.4<.001.002
Maternal anxiety at 32 wk
 1st quartile (0-2)70/1582 (4.2%)1 (reference)1 (reference)47/1582 (2.9%)1 (reference)1 (reference)
 2nd quartile (3-4)62/1232 (4.8%)1.14 (0.80-1.61)1.08 (0.76-1.54)59/1232 (4.6%)1.61 (1.09-2.38)1.57 (1.06-2.33)
 3rd quartile (5-7)76/1308 (5.5%)1.31 (0.94-1.83)1.27 (0.90-1.77)68/1308 (4.9%)1.75 (1.20-2.56)1.72 (1.17-2.51)
 4th quartile 8-16)63/953 (6.2%)1.49 (1.05-2.12)1.43 (1.00-2.05)54/953 (5.4%)1.91 (1.28-2.84)1.80 (1.20-2.70)
 P (trend).02.03.001.003
*Adjusted for sex, preterm delivery, multiple birth, number of siblings, maternal age, maternal education, maternal history of asthma and allergy, prenatal tobacco smoke exposure, and problems during pregnancy (diabetes, hypertension, steroid intake)