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Associations of maternal anxiety symptoms at 18 weeks of gestation (stratified by reactive and nonreactive to life events) with children's asthma at 7½ years

OR (95% CI) for current asthma at 7½ y
N asthma/no asthma (% with asthma)CrudeAdjusted*
Maternal reactive anxiety at 18 wk
 1st quartile (0-2)99/781 (11.3)1 (reference)1 (reference)
 2nd quartile (3-4)100/661 (13.1)1.19 (0.89-1.61)1.13 (0.84-1.53)
 3rd quartile (5-7)131/845 (13.4)1.22 (0.93-1.62)1.20 (0.90-1.59)
 4th quartile (8-16)127/660 (16.1)1.52 (1.14-2.01)1.38 (1.03-1.85)
 P (trend).005.029
Maternal anxiety trait at 18 wk
 1st quartile (0-2)99/948 (9.5)1 (reference)1 (reference)
 2nd quartile (3-4)73/512 (12.5)1.37 (0.99-1.88)1.33 (0.96-1.85)
 3rd quartile (5-7)68/444 (13.3)1.47 (1.06-2.04)1.46 (1.04-2.05)
 4th quartile (8-16)36/207 (14.8)1.67 (1.11-2.51)1.71 (1.12-2.62)
 P (trend).004.004
*Adjusted for sex, preterm delivery, multiple birth, number of siblings, maternal age, maternal education, maternal history of asthma and allergy, prenatal tobacco smoke exposure, and problems during pregnancy (diabetes, hypertension, steroid intake).