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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Cancer Res. Author manuscript; available in PMC 2010 August 1.
Published in final edited form as:
Cancer Res. 2009 August 1; 69(15): 6021–6026.
Published online 2009 July 21. doi: 10.1158/0008-5472.CAN-09-1086

Figure 4

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Evaluation of LLC and B16 tumors in TEM8+/+ and TEM8−/− mice. A, Tumor growth following s.c. tumor cell injection. n = 6–9 for LLC; n = 12–13 for B16. Points, means; bars, SE; *, P < 0.005; **, P < 0.002 (student’s t test). B, Vessel density in B16 tumors. Immunofluorescence staining of ECs (Meca-32, red) and pericytes pericytes (Desmin, green). Bar, 100µm. C, The number of pericytes in B16 tumors. Arrowheads, pericyte nuclei; Bar, 10µm. D, qPCR analysis of TEM8 and CMG2 expression in B16 or LLC tumor cells in culture, or purified tumor ECs (T-ECs). Error bars represent SD derived from biological replicates (separate flasks of cultured cells or independently isolated T-EC samples).

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