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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
IUBMB Life. Author manuscript; available in PMC 2010 July 1.
Published in final edited form as:
IUBMB Life. 2009 July; 61(7): 713–722.
doi: 10.1002/iub.196

Figure 1

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Object name is nihms100453f1.jpg
The import of peroxisomal matrix proteins

(1) Cargoes are bound by a soluble receptor/s (Pex5 for PTS1 cargoes, Pex7 and PTS2 co-receptors for PTS2 cargoes, not depicted). (2) The receptor-cargo complex docks at the peroxisome membrane with the docking subcomplex. (3) The translocon is assembled and the receptor-cargo complex translocates into the peroxisome matrix. (4) The receptor-cargo complex is disassembled in the peroxisome matrix, causing cargo release. (5) Receptors are exported to the peroxisome membrane. (6a) Receptors are mono-ubiquitinated by Pex4 (for recycling) or (6b) poly-ubiquitinated by ubc4/5 (for degradation by the RADAR pathway). (7a) Receptors are recycled to the cytosol by the action of the AAA ATPases, Pex1 and Pex6, or (7b) degraded via the RADAR pathway involving the proteasome. (8) Receptors are deubiquitinated and utilized for the next round of import.