We thank Mr. T. Minamide and Mr. T. Matsuoka, ONO Pharmaceutical Co., Ltd., for their scientific and technical support, Astellas Pharmaceutical, for providing supportive data, and the following investigators and clinical sites in Japan that participated in this study: T. Ota, Ota Orthopedic Clinic; M. Kokaji, M. Tsuji, S. Kawamura, Kobayashi Hospital; T. Hashimoto, Hakodate Koseiin Hakodate Central General Hospital; S. Sato, Eniwa Hospital; G. Katahira, Sapporo Kiyota Orthopeadic Hospital; Y. Saito, Hokuei Orthopedics; S. Nabeshima, Nabeshima Clinic; T. Fukunaga, Ainosato Orthopedics; T. Chiba, Kikusui Orthopedics; H. Yamamoto, Toyohira Orthopedics; H. Koga, Koga Orthopedic Clinic; T. Ando, Morioka Hospital; S. Tsukikawa, Tsukikawa Lady’s Clinic; S. Harada, Tsukuba Gakuen Hospital; N. Tajima, Tajima Geka Ichouka; K. Ogata, Seiwakai Shoda Hospital; T. Michimata, Uchibori Seikeigeka Iin; H. Inoue, Inoue Hospital; M. Inuzuka, Chousei Hospital; S. Ichikawa, Cardiovascular Hospital of Center Japan; K. Toba, Toba Orthopedic Clinic; H. Sato, Saiseikai Kawaguchi General Hospital; Y. Kaneda, Kaneda Orthopedics; K. Inoue, Tokyo Women`s Medical University Medical Center East; S. Yamada, Kyoai Clinic; K. Fukuda, Shiratori Clinic; S. Sano, Sanraku Hospital; A. Yamaguchi, Yamaguchi Hospital; T. Nakamura, Abe Clinic; K. Maruyama, Gate Town Hospital; T. Nakagawa, Senpo Tokyo Takanawa Hospital; T. Takemoto, Misyuku Hospital; K. Kamada, Kumegawa Hospital; H. Mizuguchi, T. Ryu, Y. Sakamoto, S. Katayama, Mizuguchi Hospital; R. Kimura, Hideshima Hospital; S. Yamaguchi, Gonohashi Clinic; C. Nokubo, Nokubo Orthopedic Clinic; M. Takemoto, Takemoto Orthopedics; T. Ishihara, Shirahigebashi Hospital; Y. Tsuruta, Tsuruta Clinic; S. Yamazaki, Sengoku Hospital; T. Ishibashi, T. Okubo, Oguchi East Hospital; K. Suzuki, A. Okazaki, Shonan Daiichi Hospital; H. Machida, Kanto Rosai Hospital; S. Yamashita, Hayama Orthopedics; Y. Mikami, Yokohama Rosai Hospital; I. Miyata, Aoba Orthopedics Clinic; M. Kasuga, Kasuga Orthopedics; M. Tsuboi, Yokohama Minoru Clinic; N. Nagata, Nagata Orthopedics; N. Endo, Niigata University Medical & Dental Hospital; Y. Murai, Murai Orthopedic Iin; S. Noto, Noto Orthopedics; M. Katsumi, Katsumi Orthopedics; H. Morishita, T. Takino, Kanazawa Social Insurance Hospital; N. Hachisuka, Hachisuka Orthopedics; M. Takimori, Nirasaki Mutual Hospital; Y. Nagasaka, Nagasaka Orthopedics; M. Suzuki, Suzuki Orthopedic Iin; S. Kumaki, Hokushin General Hospital; S. Kobayashi, Shinsyu University Hospital; T. Hanaoka, Yamabe Spa Hanaoka Orthopedics; H. Misawa, Yodakubo Hospital; M. Shiraki, Research Institute and Practice for Involutional Diseases; S. Tsuboi, Shizuoka Kosei Hospital; K. Yamazaki, Hamamatsu University School of Medicine University Hospital; M. Taniguchi, Taniguchi Orthopedic Iin; M. Fukuchi, Aobadai Fukuchi Orthopedics & Gastroenterology Clinic; M. Denda, Denda Orthopedics; Y. Nishijima, Nishijima Hospital; T. Kitakoji, Nagoya University Hospital; Y. Hachiya, Hachiya Orthopedic Hospital; Y. Osaka, Minamiosaka Hospital; A. Tei, Kishiwada Tokushukai Hospital; Y. Honda, Baba Memorial Hospital; N. Sha, Kanebo Memorial Hospital; T. Noda, C. Terada, Ako Central Hospital; J. Sako, Irie Hospital; Y. Higashi, Himeji Central Hospital; T. Onishi, Onishi Orthopedics; T. Matsubara, Matsubara Clinic; Y. Koyama, Matsubara Mayflower Hospital; S. Soen, Kinki University School of Medicine, Nara Hospital; M. Ozaki, Kitade Hospital; M. Ohama, Yonago East Hospital; T. Nishiyama, Tamashima Daiichi Hospital; H. Sanada, Sanada Hospital; K. Sanuki, Sanuki Orth & Rheumatic Clinic; T. Taguchi, Yamaguchi University Hospital; S. Yamagata, Yamagata Iin; K. Nobutani, Sea Side Hospital; H. Yamazaki, H. Ueno, Mine City Hospital; S. Ono, Marugame Ono Clinic; A. Kuge, S. Morita, Izumino Hospital; T. Ogata, Ogata Orthopedic Hospital; H. Ikematsu, Haradoi Hospital; A. Iwaki, K. Domen, Okabe Hospital; Y. Ishibashi, Ishibashi Orthopedics; T. Tsuruta, Tsuruta Orthopaedic Clinic; H. Shibata, Shibata Chokodo Hospital; T. Segata, Kumamoto Saishunso National Hospital; T. Naono, Oita Oka Hospital; E. Nakamura, Nakamura Hospital; S. Okamoto, Sanyo Osteoporosis Research Foundation Okamoto Naika Clinic; S. Nagai, Kagoshima Red Cross Hospital; H. Sakamoto, Sakamoto Medical Clinic. The present study was sponsored by ONO Pharmaceutical Co., Ltd. and Astellas Pharmaceutical.
Conflicts of interest None of the authors are or were employed by Astellas Pharmaceutical or Ono Pharmaceutical.Drs. Matsumoto, Hagino, Shiraki, Fukunaga, Nakano, Takaoka, Ohashi and Nakamura have received consultant/honorarium fees from Astellas and Ono.
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