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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
Gastroenterology. Author manuscript; available in PMC 2010 July 1.
Published in final edited form as:
Gastroenterology. 2009 July; 137(1): 110–118.
Published online 2009 April 9. doi: 10.1053/j.gastro.2009.04.005

Table 2

The sensitivity and specificity of AFP, DCP and AFP-L3% using the current clinical cutoffs.

MarkerCutoffSensitivity % (95%CI)Specificity % (95%CI)
All HCC (n=419)
AFP2059 (55–64)90 (86–93)
DCP15074 (70–79)70 (65–74)
AFP-L31042 (37–47)97 (93–100)
AFP+DCPAFP=20 or DCP=15086 (82–89)63 (58–67)
Early Stage HCC (n=208)*
AFP2053 (46–59)90 (87–93)
DCP15061 (55–68)70 (65–74)
AFP-L31028 (22–34)97 (93–100)
AFP+DCPAFP=20 or DCP=15078 (72–83)62 (58–67)

DCP= des-gamma carboxyprothrombin in mAU/mL, AFP= alpha-fetoprotein in ng/mL, AFP-L3 = % of AFP that is fucosylated. CI= confidence intervals.

*Very early (BCLC stage 0) + early stage (BCLC stage A) HCC based on Barcelona staging classification.