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J Clin Microbiol. 1986 December; 24(6): 982–985.
PMCID: PMC269083

Comparison of cerebrospinal fluid C-reactive protein and lactate for diagnosis of meningitis.


Levels of C-reactive protein and lactate were determined on 562 consecutive cerebrospinal fluid (CSF) samples from adult patients with a wide variety of central nervous system diseases to compare the sensitivity and specificity of CSF lactate and C-reactive protein for the rapid diagnosis of bacterial meningitis. Neither test alone, together, or in combination with elevated CSF leukocyte count and protein had a predictive value over 60% for a positive test in this group of patients with diverse central nervous system problems. Neither test is useful as a screening test for bacterial or mycotic meningitis. Also, in patients with partially treated bacterial meningitis, the tests are often negative. CSF lactate may be useful in differentiating aseptic from septic meningitis in selected patients.

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Selected References

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  • Abramson JS, Hampton KD, Babu S, Wasilauskas BL, Marcon MJ. The use of C-reactive protein from cerebrospinal fluid for differentiating meningitis from other central nervous system diseases. J Infect Dis. 1985 May;151(5):854–858. [PubMed]
  • Benjamin DR, Opheim KE, Brewer L. Is C-reactive protein useful in the management of children with suspected bacterial meningitis? Am J Clin Pathol. 1984 Jun;81(6):779–782. [PubMed]
  • Briem H. Comparison between cerebrospinal fluid concentrations of glucose, total protein, chloride, lactate, and total amino acids for the differential diagnosis of patients with meningitis. Scand J Infect Dis. 1983;15(3):277–284. [PubMed]
  • Corrall CJ, Pepple JM, Moxon ER, Hughes WT. C-reactive protein in spinal fluid of children with meningitis. J Pediatr. 1981 Sep;99(3):365–369. [PubMed]
  • de Zegher F, Ben Gershôm E, Briggeman-Mol GJ. C-reactive protein in case of consecutive bacterial and viral meningitis. Lancet. 1984 Dec 22;2(8417-8418):1465–1466. [PubMed]
  • Donald PR, Strachan AF, Schoeman JF, De Beer FC. Cerebrospinal fluid C-reactive protein in infective meningitis in childhood. J Lab Clin Med. 1985 Oct;106(4):424–427. [PubMed]
  • Komorowski RA, Farmer SG, Hanson GA, Hause LL. Cerebrospinal fluid lactic acid in diagnosis of meningitis. J Clin Microbiol. 1978 Jul;8(1):89–92. [PMC free article] [PubMed]
  • Macfarlane DE, Narla VR. Cerebrospinal fluid C-reactive protein in the laboratory diagnosis of bacterial meningitis. Acta Paediatr Scand. 1985 Jul;74(4):560–563. [PubMed]
  • Marbach EP, Weil MH. Rapid enzymatic measurement of blood lactate and pyruvate. Use and significance of metaphosphoric acid as a common precipitant. Clin Chem. 1967 Apr;13(4):314–325. [PubMed]
  • Peltola HO. C-reactive protein for rapid monitoring of infections of the central nervous system. Lancet. 1982 May 1;1(8279):980–982. [PubMed]
  • Philip AG, Baker CJ. Cerebrospinal fluid C-reactive protein in neonatal meningitis. J Pediatr. 1983 May;102(5):715–717. [PubMed]
  • Valmari P, Peltola H, Ruuskanen O. C-reactive protein as predictor of sequelae of meningitis. Lancet. 1984 Mar 31;1(8379):741–742. [PubMed]
  • Van Lente F. The diagnostic utility of C-reactive protein. Hum Pathol. 1982 Dec;13(12):1061–1063. [PubMed]
  • DOERNER AA, YOCUM RS. A clinical evaluation of the C-reactive protein test. AMA Arch Intern Med. 1957 Jan;99(1):74–81. [PubMed]

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