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BMC Genomics. 2009; 10: 230.
Published online 2009 May 18. doi:  10.1186/1471-2164-10-230
PMCID: PMC2689278

The extracellular Leucine-Rich Repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns

Abstract

Correction to Dolan J, Walshe K, Alsbury S, Hokamp K, O'Keeffe S, Okafuji T, Miller SF, Tear G, Mitchell KJ: The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics 2007, 8:320.

Correction

In our original article [1] a mistake was made in Figure Four in the depiction of the structure of the Drosophila gene CG8561, now called Als or dAls (Drosophila acid-labile subunit). The correct structure is shown here in Figure Figure1,1, based on a newly-available and slightly extended sequence of CG8561 from the Ensembl database (FBpp0086669). This gene should have been shown to encode a secreted protein with 29 LRR domains, an N-terminal LRR-NT and a C-terminal LRR-CT domain, based on the LRRscan programme output. Use of the new sequence does not alter the clustering relationships of the CG8561 protein, shown in Figure Two and in Additional Files Three-Five of the original paper. We note that these data, derived from TribeMCL, which simultaneously takes all pairwise relationships across all members of the proteomes of the four species used into account, do not provide strong support for direct one-to-one orthology between CG8561 and mammalian Igfals.

Figure 1
eLRR protein predicted architectures (part 2). Consensus architectures are shown for all proteins in the LRR_Tollkin and LRR_Other groups. An additional set of LRR_Only singletons is listed separately in Table 1. Protein names are shown below the corresponding ...

The reassignment of structure also changes the figures in Table Two (shown here as Table Table1).1). There should be 11 type I transmembrane and 4 secreted proteins in flies in the LRR-Tollkin subgroup.

Table 1
Complement of eLRR proteins by group, localisation and species

References

  • Dolan J, Walshe K, Alsbury S, Hokamp K, O'Keeffe S, Okafuji T, Miller SF, Tear G, Mitchell KJ. The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics. 2007;8:320. doi: 10.1186/1471-2164-8-320. [PMC free article] [PubMed] [Cross Ref]

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