This study was supported by a grant (U01-AG10483) from the National Institute on Aging, as well as grants from the General Clinical Research Center Program of the National Center for Research resources, National Institutes of health. Folic acid and vitamin B6 and B12 were donated by Roche. Participating investigators, data and safety monitoring board members and clinical monitors for the study are listed at the end of this article. None of the authors of this manuscript have any potential conflicts of interest. The corresponding author had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Participating Investigators and Staff: Southern Illinois University, Springfield: Sandra Vicari, PhD, Thomas Ala, MD, Karen Luster, RN; Oregon Health & Science University, Portland: Joseph Quinn, MD, Joyce Lear, RN, MN, Tera Clay; University of Southern California, Los Angeles: Lon S. Schneider, MD, Sonia Pawluczyk, MD, Karen Dagerman, MA, Shirley Sian; University of California, San Diego: Adam Fleisher, MD, MAS, Mary M. Pay, APRN; University of Michigan, Ann Arbor: Nancy Barbas, MD, MSW, Joanne Lord, LPN, BA, CCRC; University of Washington, Seattle: Elaine Peskind, MD, Murray A. Raskind, MD, Linda Mandelco; Baylor College of Medicine, Houston: Rachelle S. Doody, MD, PhD, Jamie Sims, BS, Susan Roundtree, MD; Columbia University, New York: Karen Bell, MD, Ruth Tejeda, MD, Evelyn Dominguez-Rivera, MD; University of Alabama at Birmingham: Linda Harrell, MD, PhD, Daniel Marson, JD, PhD, Edward Zamrini, MD; Mount Sinai School of Medicine, Bronx: Hillel Grossman, MD, George Marzloff, BS, Sirisha Nandipait, BA; Rush University Medical Center, Chicago: Neelum Aggarwal, MD, Raj Shah, MD, Julie Bach, CSW; University of South Florida, Tampa: Eric Pfeiffer, MD, Barbara Luhn, MSW, CCRC, Jennifer Hunter, MA; New York University Medical Center, New York: Steven H. Ferris, PhD, Isabel Monteiro, MD, Erica Maya, BA; University of Pennsylvania, Philadelphia: Christopher Clark, MD, Monica Han, BA, Cassie Pham, BS, Marianne Watson, RN; University of Pittsburgh: Steven T. DeKosky, MD, Donna Simpson CRNP, MPH; University of Rochester: Saleem M. Ismail, MD, Bonnie Goldstein, RN, Coleen McCallum, MSW; University of California, Irvine: Ruth A. Mulnard, RN, DNSc, FAAN, Catherine McAdams-Ortiz, RN, MSN, A/GNP, Beatriz Yanez, BA; University of Texas, Southwestern Medical Center at Dallas: Myron Weiner, MD, Kathleen Koch, RN, MN, CCRC, Carol Moore, MA; Emory University, Atlanta: Allan Levey, MD, PhD, Janet Cellar, RN, MSN, Andrea Kippels, RN, MSN; University of California, Los Angeles: John Ringman, MD, Jenny Bardens, RN, Alice Yau; Mayo Clinic, Jacksonville: Neill R. Graff-Radford, MD, Francine Parfitt, MS; Indiana University, Indianapolis: Martin R. Farlow, MD, Ann Hake, MD, Patricia Numberger, RN; Yale University, New Haven: Christopher van Dyck, MD, Martha MacAvoy, PhD, Nicole Black, BA, Pamela Hoffman, BS; University of California, Davis: Charles DeCarli, MD, William Seavey, MD, Cassandra Conover, RN; University of Arizona, Tucson: Geoffrey Ahern, MD, PhD, Marjorie Baldwin, RN, BSN, Mike Malek-Ahmadi, BA; University of Nevada, Las Vegas: Charles Bernick, MD, Donna Munic, PhD, Gail Vranesh, RN; Northwestern University, Chicago: Marsel Marek-Mesulam, MD, Nancy Johnson, PhD, Stephanie Epstein-Fields, MA; Medical University of South Carolina, North Charleston: Jacobo E. Mintzer, MD, Fay Ann Davis, LPN; ClinSearch, Inc., Kenilworth: Justine Kent, MD, Mark Roffman, PhD; Premiere Research Institute, West Palm Beach: Carl Sadowdky, MD, Teresa Villena, MD, Walter C. Martinez, MD; Georgetown University, Washington: Kathleen Johnson, NP, Brigid Reynolds, NP, Carolyn Ward, MSPH; Brigham and Women’s Hospital, Boston: Sibyl Salisbury, BS; Stanford/VA Aging Clinical Research Center, Stanford: Jerome A. Yesavage, MD, Wesson J. Ashford, MD, Alena Pechonkina, MD, Lisa Kinoshita, PhD; Sun Health Research Institute, Sun City: Marwan Sabbagh, MD, FAAN, Donald Connor, PhD, Sanja Obradov, CCRD; Boston University SOM, Boston: Robert C. Green, MD, MPH, Robert A. Stern, PhD, Anil Nair, MD, Margarget Brickley, MS, ACNP, GNP-BC; Mayo Clinic, Scottsdale: Richard Caselli, MD, Judy Lawrence, RN; Howard University, Washington DC: Thomas Obisesan, MD, MPH, Odunayo A. Obisesan, PharmD, Ezenwanyi Ahaghotu, MS; Case Western Reserve University, Cleveland: Paul Ogrocki, PhD, Marianne Sanders, RN, Elaine Ziol, MHS, CCRC; Rhode Island Hospital, Providence: Brian R. Ott, MD, Janet Grace, PhD, Teresa Erbozkurt, MA.
Data and Safety Monitoring Board: University of Rochester School of Medicine and Dentistry: Karl Kieburtz, MD; University of California, San Francisco: Bruce Miller, MD; University of Kentucky, Lexington: Richard Kryscio, PhD; Weill Cornell Medical College: George Alexopoulos, MD.
Clinical Monitors: University California, San Diego: Karen Croot, BA, Viviana Messick, BS, Alan Pamoleras, BA, Rebecca Ryan-Jones, PhD; Mount Sinai School of Medicine: Gina Garcia-Camilo, MD, Mario Schittini, MD, MPH; Georgetown University: Kris Gravanda Brugger, BA, Pamela A. Saunders, PhD; New York University: Janet Kastelan, MA.