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Logo of gseBioMed CentralBiomed Central Web Sitesearchsubmit a manuscriptregisterthis articleGenetics, Selection, Evolution : GSEJournal Front Page
Genet Sel Evol. 2007; 39(3)
Published online Apr 14, 2007. doi:  10.1186/1297-9686-39-3-225
PMCID: PMC2682824
Managing the risk of comparing estimated breeding values across flocks or herds through connectedness: a review and application
Larry A Kuehn,corresponding author1 Ronald M Lewis,1 and David R Notter1
1Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
corresponding authorCorresponding author.
Larry A Kuehn: Larry.Kuehn/at/ARS.USDA.GOV
Received June 6, 2006; Accepted January 6, 2007.
Comparing predicted breeding values (BV) among animals in different management units (e.g. flocks, herds) is challenging if units have different genetic means. Unbiased estimates of differences in BV may be obtained by assigning base animals to genetic groups according to their unit of origin, but units must be connected to estimate group effects. If many small groups exist, error of BV prediction may be increased. Alternatively, genetic groups can be excluded from the statistical model, which may bias BV predictions. If adequate genetic connections exist among units, bias is reduced. Several measures of connectedness have been proposed, but their relationships to potential bias in BV predictions are not well defined. This study compares alternative strategies to connect small units and assesses the ability of different connectedness statistics to quantify potential bias in BV prediction. Connections established using common sires across units were most effective in reducing bias. The coefficient of determination of the mean difference in predicted BV was a perfect indicator of potential bias remaining when comparing individuals in separate units. However, this measure is difficult to calculate; correlated measures such as prediction errors of differences in unit means and correlations among prediction errors are suggested as practical alternatives.
Keywords: connectedness, genetic evaluation, bias, genetic groups, breeding value
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