Search tips
Search criteria 


Logo of biolettersThe Royal Society PublishingBiology LettersAboutBrowse By SubjectAlertsFree Trial
Biol Lett. 2009 June 23; 5(3): 394–396.
Published online 2009 February 25. doi:  10.1098/rsbl.2008.0762
PMCID: PMC2679914

Upper-limit mutation rate estimation for a plant RNA virus


It is generally accepted that mutation rates of RNA viruses are inherently high due to the lack of proofreading mechanisms. However, direct estimates of mutation rate are surprisingly scarce, in particular for plant viruses. Here, based on the analysis of in vivo mutation frequencies in tobacco etch virus, we calculate an upper-bound mutation rate estimation of 3×10−5 per site and per round of replication; a value which turns out to be undistinguishable from the methodological error. Nonetheless, the value is barely on the lower side of the range accepted for RNA viruses, although in good agreement with the only direct estimate obtained for other plant viruses. These observations suggest that, perhaps, differences in the selective pressures operating during plant virus evolution may have driven their mutation rates towards values lower than those characteristic of other RNA viruses infecting bacteria or animals.

Keywords: experimental evolution, mutation rate, plant virus, virus evolution

Articles from Biology Letters are provided here courtesy of The Royal Society