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Biol Lett. Jun 23, 2009; 5(3): 421–424.
Published online Feb 25, 2009. doi:  10.1098/rsbl.2008.0729
PMCID: PMC2679908
An examination of phylogenetic models of substitution rate variation among lineages
Simon Y.W. Ho*
Centre for Macroevolution and Macroecology, School of Biology, Australian National University, Canberra, Australian Capital Territory 0200, Australia
* (simon.ho/at/
Received December 3, 2008; Accepted January 9, 2009.
Molecular evolutionary rates can show significant variation among lineages, complicating the task of estimating substitution rates and divergence times using phylogenetic methods. Accordingly, relaxed molecular clock models have been developed to accommodate such rate heterogeneity, but these often make the assumption of rate autocorrelation among lineages. In this paper, I examine the validity of this assumption.
Keywords: rate autocorrelation, relaxed clocks, divergence dating, mutation rate, substitution rate, life history
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