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Biol Lett. 2009 June 23; 5(3): 421–424.
Published online 2009 February 25. doi:  10.1098/rsbl.2008.0729
PMCID: PMC2679908

An examination of phylogenetic models of substitution rate variation among lineages


Molecular evolutionary rates can show significant variation among lineages, complicating the task of estimating substitution rates and divergence times using phylogenetic methods. Accordingly, relaxed molecular clock models have been developed to accommodate such rate heterogeneity, but these often make the assumption of rate autocorrelation among lineages. In this paper, I examine the validity of this assumption.

Keywords: rate autocorrelation, relaxed clocks, divergence dating, mutation rate, substitution rate, life history

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